A Method for Quantitatively Evaluating the Mixing Condition of Alcohol Precipitation Process

A quantitative evaluation and alcohol precipitation technology, which is applied in the direction of settling tanks, measuring devices, and material weighing, etc., can solve the problems that there is no method for quantitatively evaluating the mixing effect of ethanol solution and concentrated liquid, and achieve clear physical meaning, low cost, good repeatability

Active Publication Date: 2022-02-01
ZHEJIANG UNIV
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Problems solved by technology

However, there is currently no method that can quantitatively evaluate the mixing effect of ethanol solution and concentrate in the alcohol precipitation process

Method used

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  • A Method for Quantitatively Evaluating the Mixing Condition of Alcohol Precipitation Process
  • A Method for Quantitatively Evaluating the Mixing Condition of Alcohol Precipitation Process
  • A Method for Quantitatively Evaluating the Mixing Condition of Alcohol Precipitation Process

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Effect test

Embodiment 1

[0020] According to literature research and preliminary experimental results, tangshenoside was selected as the indicator of mixing conditions in Codonopsis pilosula concentrate. Codonopsis pilosula medicinal material is extracted by heating water, concentrated under reduced pressure, concentrated for a period of time to obtain Codonopsis pilosula concentrate, and the solid content of the concentrate obtained after testing is 55%. The content of tangshenoside in the concentrated liquid was detected by liquid chromatography to be 224.06 μg / g. Then use the concentrated solution to carry out stirring alcohol precipitation, the concentrated solution consumption is 41.3g, and the ethanol consumption is 62.0g. Stir for 5 minutes after adding ethanol, and filter to obtain 76.5 g of alcohol precipitation supernatant. After detection, the solid content in the supernatant of alcohol precipitation was 13.34%, and the content of tangshenoside in the supernatant was 72.98 μg / g. The total...

Embodiment 2

[0022] According to literature research and preliminary experimental results, tangshenoside was selected as the indicator of mixing conditions in Codonopsis pilosula concentrate. Codonopsis pilosula is extracted by heating water, concentrated under reduced pressure, concentrated for a period of time to obtain Codonopsis pilosula concentrate, and the solid content of the concentrate obtained after testing is 50%. The content of tangshenoside in the concentrated liquid was detected by liquid chromatography to be 219.34 μg / g. Then use the concentrated solution to carry out membrane dispersion alcohol precipitation, the amount of the concentrated solution is 32.5 g, and the amount of ethanol is 53.9 g. After adding ethanol, stir for 5 minutes, and filter to obtain 74.4 g of alcohol precipitation supernatant. After detection, the solid content in the supernatant of alcohol precipitation was 11.04%, and the content of tangshenoside in the supernatant was 90.93 μg / g. The total amou...

Embodiment 3

[0024] According to literature research and preliminary experimental results, tangshenoside was selected as the indicator of mixing conditions in Codonopsis pilosula concentrate. Codonopsis pilosula is extracted by heating water, concentrated under reduced pressure, concentrated for a period of time to obtain Codonopsis pilosula concentrate, and the solid content of the concentrate obtained after testing is 60%. The content of tangshenoside in the concentrated liquid was detected by liquid chromatography to be 211.30 μg / g. Then use the concentrated solution to carry out membrane dispersion alcohol precipitation, the amount of the concentrated solution is 38.7g, and the amount of ethanol is 64.7g. Stir for 5 minutes after adding ethanol, and filter to obtain 75.7 g of alcohol precipitation supernatant. After detection, the solid content in the supernatant of alcohol precipitation was 7.17%, and the content of tangshenoside in the supernatant was 79.34 μg / g. The total amount o...

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Abstract

The invention discloses a method for quantitatively evaluating the mixing condition of the alcohol precipitation process. The steps include: a first step, determining component A in the concentrated solution as a mixing condition indicator; a second step, measuring key indicators of the concentrated solution used for alcohol precipitation; The third step is to implement the alcohol precipitation process and obtain the alcohol precipitation supernatant, and record the key parameters of the alcohol precipitation process; the fourth step is to measure the key indicators of the alcohol precipitation supernatant; the fifth step is to use the formula to calculate the alcohol precipitation process and The ratio WMR of the ethanol solution to the fully mixed concentrate. The invention creates a quantitative evaluation method for alcohol precipitation and mixing conditions, solves the long-standing problem of indistinguishable alcohol precipitation package loss and precipitation loss, and provides a beneficial basis for improving the quality and efficiency of the traditional Chinese medicine manufacturing process.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a method for quantitatively evaluating the mixing situation in the alcohol precipitation process. Background technique [0002] Alcohol precipitation is a refining process widely used in the production of traditional Chinese medicine. It can be realized as long as the ethanol solution is passed into the concentrated solution of traditional Chinese medicine. It has many advantages such as simple operation, easy amplification, and safe solvent. Among the 1,493 preparations of prescriptions and single preparations included in the 2015 edition of "Chinese Pharmacopoeia" (Part One), 274 Chinese herbal medicines involve the alcohol precipitation process, accounting for 18.4%. Although it is widely used, it has been observed in experimental research and industrial production that there is a loss of active ingredients during the alcohol precipitation process. It is generall...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/02G01N5/00B01D21/02
CPCG01N30/06G01N30/02G01N5/00B01D21/02
Inventor 瞿海斌程翼宇龚行楚
Owner ZHEJIANG UNIV
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