Lung experiment model system for simulating bioaerosol deposition

Abstract

The invention discloses a lung experiment model system for simulating bioaerosol deposition, which relates to the field of respiratory protection and comprises a bioaerosol exposure experiment cabin,a lung model, a bioaerosol generating and sampling system, a respiratory simulation and monitoring system and the like. A bioaerosol uniform diffuser, a bioaerosol generator and a bioaerosol sampler are mounted at the top of the bioaerosol exposure experiment cabin, the lung model is fixed in a lung model sealed cabin, and the lung model sealed cabin is placed in the middle of the bottom of the bioaerosol exposure experiment cabin; the lung model comprises a left lung transparent flexible model, a right lung transparent flexible model, a transparent throat, a trachea and 2-4 levels of bronchuswhich jointly form a respiratory system model conforming to physiological characteristics of a human body, and the respiratory system model is connected with a bioaerosol sampler and a simulated breathing pump. The system can simulate the deposition and distribution of the biological aerosol in the respiratory system of the human body in a real breathing mode.

Description

technical field [0001] The invention relates to the technical field of pathogenic microorganism respiratory invasion research, in particular to a lung experiment model system for simulating biological aerosol deposition. Background technique [0002] Pathogenic microorganisms enter the human trachea, bronchus and even lungs under the action of respiration in the form of bioaerosols, which is the main way to cause outbreaks of various infectious diseases such as influenza. Therefore, the study of pathogenic microorganisms entering the human respiratory system is characterized by the prevention of various respiratory diseases important means of control. Traditional animal models cannot fully conform to the characteristics of the human body, and there are large deviations in the research results. There are major safety hazards in real human experiments, and the cost is relatively high. Therefore, the construction of an in vitro experimental model that can simulate the charact...

AI Technical Summary

Problems solved by technology

However, the existing models all simulate physical aerosols such as atmospheric dust, and most of them are local bronchial models, which cannot truly reflect the deposition of bioaerosols carrying pathogenic microorganisms in the human respiratory system

None of the existing experimental models involve the whole lung model, either a partial model of the trachea and bronchus, or an enlarged model of a group of alveoli, which has certain limitations in application

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