Supercharge Your Innovation With Domain-Expert AI Agents!

Oxygen-containing heterocyclic compound for treating cerebral apoplexy

A compound, stroke technology, applied in the direction of organic chemistry, drug combination, medical preparations containing active ingredients, etc., to achieve good therapeutic activity and broaden the scope of the effect

Active Publication Date: 2021-01-12
THE SECOND PEOPLES HOSPITAL OF SHENZHEN
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, although various chemical drugs and natural drugs are in different research stages, there is no drug that splices edaravone and coumarin fragments among the currently marketed stroke drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oxygen-containing heterocyclic compound for treating cerebral apoplexy
  • Oxygen-containing heterocyclic compound for treating cerebral apoplexy
  • Oxygen-containing heterocyclic compound for treating cerebral apoplexy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the synthesis of compound I

[0022] Under ice bath conditions, compound 2 (190mg, 1mmol), dicyclohexylcarbodiimide (413mg, 2mmol), 4-dimethylaminopyridine (244mg, 2mmol) and 10mL of dichloromethane were added to a 150mL three-necked flask , stirred for 20min, added compound 3 (209mg, 1.1mmol) in dichloromethane (15mL) solution, after the addition was completed, the temperature was raised to reflux temperature for 8h reaction, after the reaction was detected by TLC, the reaction solution was cooled to room temperature, and 30mL of water was added. After static liquid separation, the organic phase was concentrated under reduced pressure, and then separated by silica gel column chromatography to obtain the target product I as a white solid with a yield of 41% and a purity of 98.1% by HPLC.

[0023] Molecular formula: C 20 h 14 N 2 o 5 ;ESI-MS: 363.17[M+H] +

[0024] 1 H NMR (400MHz, CDCl 3 )δ2.24(s, 3H), 2.52(s, 2H), 6.07(dd, 1H), 7.22(d, 2H), 7.54(d...

Embodiment 2

[0025] Embodiment 2: The effect of the compound shown in formula I in treating ischemic stroke

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a compound for preventing and treating cerebral apoplexy, particularly ischemic cerebral apoplexy, which exhibits good therapeutic activity in a mouse cerebral ischemia reperfusion test, can significantly reduce the proportion of cerebral infarction, and can be used for preventing and treating cerebral apoplexy, particularly ischemic cerebral apoplexy.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to a compound for preventing and treating stroke, especially ischemic stroke, and also relates to a preparation method, pharmaceutical composition and use of the compound. Background technique [0002] In recent years, the incidence of stroke in my country has ranked first in the world. The results of the third national cause of death survey confirmed that stroke has become the first cause of death in my country, and the annual growth rate exceeds 8.7%, which has seriously affected the lives and health of Chinese people. Stroke is mainly divided into two types: ischemic stroke (IS) and hemorrhagic stroke (HS). Among them, IS type patients account for three-quarters of the total incidence of patients and are the main cause of stroke. Types of. The key to the treatment of IS is "early diagnosis and early intervention". Various current treatments try to save the ischemic brain tissu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D405/12A61K31/4155A61P9/10
CPCC07D405/12A61P9/10Y02P20/55
Inventor 任力杰谭回胡诗雨冯宏业王洋雷志浩
Owner THE SECOND PEOPLES HOSPITAL OF SHENZHEN
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com