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A kind of preparation method of pumpkin polysaccharide chromium selenium complex and its products and applications

A technology of pumpkin polysaccharide and chromium complex, which is applied in the field of preparation of pumpkin polysaccharide chromium-selenium complex, can solve the problems that it is difficult to ensure the content of two trace elements at the same time, there is no activity research report, and the content of trace elements is unreasonable, etc. Immunity and anti-stress effect, improving immune function, improving the effect of animal immunity

Active Publication Date: 2022-02-22
江西九正药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing immunomodulators cannot contain chromium and selenium at the same time, and the content of trace elements in the immunomodulators is unreasonable, which leads to the destruction of the balance of trace elements in the animal body and the inhibition of growth
At the same time, inorganic substances containing trace elements are highly toxic. These trace elements with biological activity have low absorption rates of simple substances, simple inorganic substances or free metal ions, and are highly toxic.
Moreover, in the preparation of the complex, chromium and selenium have antagonistic effects, and it is difficult to ensure that the two trace elements have a high content at the same time
At present, there is no research report on the activity of pumpkin polysaccharide-chromium-selenium complexes as immunomodulators and feed additives for aquatic animals

Method used

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  • A kind of preparation method of pumpkin polysaccharide chromium selenium complex and its products and applications
  • A kind of preparation method of pumpkin polysaccharide chromium selenium complex and its products and applications
  • A kind of preparation method of pumpkin polysaccharide chromium selenium complex and its products and applications

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preparation example Construction

[0023] In order to solve the above technical problems, the first aspect of the present invention provides a method for preparing pumpkin polysaccharide chromium-selenium complex, comprising the following steps:

[0024] a. Preparation of pumpkin polysaccharide-chromium complex: Dissolve pumpkin polysaccharide in water, add chromium-containing inorganic salt solution dropwise to react, control pH to 6-9, cool down after the reaction is completed, centrifuge, take the upper solution for alcohol precipitation, and After the precipitation is dried, the pumpkin polysaccharide-chromium complex is obtained;

[0025] b. Preparation of pumpkin polysaccharide-chromium-selenium complex: add nitric acid solution to pumpkin polysaccharide-chromium complex, add barium-containing inorganic salt after pumpkin polysaccharide-chromium complex dissolves, then add selenium-containing inorganic salt solution dropwise, heat and stir Reaction, after the reaction is completed, cool down, adjust the p...

Embodiment 1

[0099] Embodiment 1 provides a kind of preparation method of pumpkin polysaccharide chromium selenium complex, comprises the following steps:

[0100] a. Preparation of pumpkin polysaccharide-chromium complex: 5g pumpkin polysaccharide (56wt% polysaccharide content; 35wt% galacturonic acid content) was dissolved in 200mL water, and 10mL CrCl concentration of 2mol / L was added dropwise. 3 The solution is reacted, the pH is controlled to be 7-8, reacted in a 75°C water bath for 2 hours, cooled, centrifuged, and the upper layer solution is taken and added with 4 times the volume of ethanol (volume fraction: 95%) for alcohol precipitation treatment, and the solution obtained by alcohol precipitation Centrifuge, collect the precipitate, freeze-dry for 8 hours and take it out to obtain the pumpkin polysaccharide-chromium complex;

[0101] b. Preparation of pumpkin polysaccharide-chromium-selenium complex: Add 200mL of nitric acid solution with a concentration of 1v% to the above-ment...

Embodiment 2

[0106] Embodiment 2 provides a kind of preparation method of pumpkin polysaccharide chromium-selenium complex, comprising the following steps:

[0107] a. Preparation of pumpkin polysaccharide-chromium complex: 6g pumpkin polysaccharide (56wt% polysaccharide content; 35wt% galacturonic acid content) was dissolved in 300mL water, and 5mL CrCl concentration of 3mol / L was added dropwise. 3 The solution is reacted, the pH is controlled to be 7-8, reacted in a 95°C water bath for 1 hour, cooled, centrifuged, and the upper layer solution is added to 5 times the volume of ethanol (volume fraction: 95%) for alcohol precipitation treatment, and the solution obtained by alcohol precipitation Centrifuge, collect the precipitate, freeze-dry for 10 hours and take it out to obtain the pumpkin polysaccharide-chromium complex;

[0108] b. Preparation of pumpkin polysaccharide-chromium-selenium complex: Add 250mL of nitric acid solution with a concentration of 1v% to the above-mentioned pumpki...

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Abstract

The invention belongs to the field of animal breeding feed and feed additives, and in particular relates to a preparation method of a pumpkin polysaccharide chromium-selenium complex, a product and an application thereof. The pumpkin polysaccharide-chromium-selenium complex prepared by the present invention forms a stable chelate complex with chromium and selenium through the polysaccharide, wherein the chromium content is 5.5-8.5wt%, and the selenium content is 1.5-3.0wt%, which can not only play a better role The functions of the original ligand and metal ions also have a synergistic effect, and its physiological properties have also been greatly improved, becoming a multifunctional substance, which improves the absorption efficiency of chromium and selenium by aquaculture animals, and reduces the effect of chromium and selenium on It is toxic to animals, has strong immunity-enhancing functions and growth-promoting functions, and can be used to prepare immunomodulators and feed additives for farmed animals; at the same time, the raw materials are easy to obtain, the preparation process of the complex is simple, cheap, convenient to produce, and has high development value.

Description

technical field [0001] The invention belongs to the field of animal feed and feed additives, and in particular relates to a preparation method of pumpkin polysaccharide chromium-selenium complex, its product and application. Background technique [0002] Immunity is the defense mechanism of the animal body itself. Modern immunology believes that immunity is the physiological response of the animal body to recognize "self" and eliminate "others". The occurrence of almost all diseases is related to the decline of autoimmunity, or the decline of body immunity due to disease, so improving autoimmunity is the basic guarantee for animal health. Therefore, immunomodulators or immune enhancers play a pivotal role in the health of animals. [0003] Polysaccharides have immune regulation and other effects, which is the commonality of polysaccharides and their main pharmacological activity. The pharmacological activity of polysaccharides works in the body mostly through glycolipids,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A23K50/80A23K20/163A23K20/20A01K61/00
CPCC08B37/00A23K50/80A23K20/163A23K20/30A01K61/00Y02A40/81
Inventor 李芳根
Owner 江西九正药业有限公司
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