Application of rosustat in medicine for inhibiting acute alcoholic fatty liver

A technology of alcoholic fatty liver and roxadustat, applied in the direction of drug combination, pharmaceutical formula, organic active ingredients, etc., to achieve the effect of inhibiting liver damage and lipid accumulation

Inactive Publication Date: 2021-01-29
ZHEJIANG JIANFENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention proposes the application of roxadustat in drugs for inhibiting acute alcoholic fatty liver, and solves the problem of drug selection for treating alcoholic fatty liver in the prior art

Method used

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  • Application of rosustat in medicine for inhibiting acute alcoholic fatty liver
  • Application of rosustat in medicine for inhibiting acute alcoholic fatty liver
  • Application of rosustat in medicine for inhibiting acute alcoholic fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] This example demonstrates the effect of roxadustat in the treatment of acute alcoholic fatty liver.

[0021] (1) Experimental animals

[0022] Male C57BL / 6J mice, 8 weeks old, weighing 22g-26g. Mice were grown in a room with constant temperature (22±2° C.) and humidity (55±2%) under a 12-hour light / dark cycle.

[0023] (2) Treatment of experimental animals

[0024] The mice were randomly divided into four groups (6 in each group), namely: blank control group, drug-added control group, blank model group and drug-added model group. The blank control group and the drug-added control group are referred to as the control group for short; the blank model group and the drug-added model group are referred to as the model group for short. The mice in the control group were fed with normal feed, and finally fed with maltodextrin of equal volume and calories; the mice in the model group were fed with high-fat food (60% kcal% fat; CAT.D12492) for 3 days, and 31.25% (vol / vol ) e...

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Abstract

The invention provides an application of rosustat in a medicine for inhibiting acute alcoholic fatty liver. Roxasstat can significantly inhibit liver injury and lipid accumulation caused by acute alcohol. According to the mechanism, rosustat plays a role in inhibiting mouse liver lipid accumulation mainly by regulating and controlling the expression of lipid synthesis key genes. The medicine is expected to become an effective medicine for clinically treating the alcoholic fatty liver.

Description

technical field [0001] The invention relates to a new application field of drugs, in particular to the application of roxadustat in drugs for inhibiting acute alcoholic fatty liver. Background technique [0002] Alcohol abuse has historically been the number one cause of severe liver disease. Alcoholic liver disease is liver damage caused by long-term heavy drinking. According to its pathological progress, it can be divided into alcoholic fatty liver, alcoholic hepatitis, alcoholic liver fibrosis and alcoholic liver cirrhosis. Among heavy drinkers, 80% have fatty liver in varying degrees, 10% to 35% can develop into alcoholic hepatitis, and 10% to 20% can develop into liver cirrhosis. Fatty liver is the most significant pathological change in the early stage of alcoholic liver disease. If this stage is controlled, it is of great significance to slow down the progressive development of alcoholic liver disease. [0003] The liver is the most important organ for alcohol metab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/472A61P1/16
CPCA61K31/472A61P1/16
Inventor 蒋晓萌杨潇潇江宏施存元
Owner ZHEJIANG JIANFENG PHARM CO LTD
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