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Application of salidroside in preparation of drug for treating or preventing carcinoma

A technology for the molecular structure of salidroside and salidroside, applied in the application field of medicine, can solve the problems of reducing the toxicity of anti-tumor drugs, affecting the survival rate of patients, etc., and achieve the effect of significantly inhibiting growth.

Pending Publication Date: 2021-02-02
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In recent years, the research and development of anti-tumor drugs has mainly faced two major problems: enhancing the targeting of anti-tumor drugs to tumor cells so that they can kill tumor cells as much as possible without damaging normal cells; reducing the toxicity of anti-tumor drugs , the occurrence of adverse events may lead to the adjustment or discontinuation of anticancer treatment, thereby affecting the survival rate of patients

Method used

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  • Application of salidroside in preparation of drug for treating or preventing carcinoma
  • Application of salidroside in preparation of drug for treating or preventing carcinoma
  • Application of salidroside in preparation of drug for treating or preventing carcinoma

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The role of salidroside in inhibiting the growth of breast cancer MCF-7 cells

[0033] 1.1 Animal model establishment

[0034] 40 SPF grade BALB / c female mice (weight 16-20g) were adaptively fed for 7 days, and then the skin of the right forelimb of nude mice was disinfected with alcohol cotton balls, MCF-7 cells growing in logarithmic phase were collected and inoculated in the right forelimb of nude mice Underarm subcutaneous, the inoculation volume is 10 6 -10 7 / only, the volume is 200uL, gently press the pinhole after inoculation to prevent the cells from being exposed. After inoculation, put them back into the breeding cage for normal feeding. Tumor formation was determined by indicators such as tumor nodules and hard texture under the skin at the inoculation site.

[0035] 1.2 Administration method and dosage

[0036] Observe the tumor growth of the mice every day until the tumor volume grows to 100-150mm 3 , carry out random grouping (every group of 8) and...

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Abstract

The invention relates to application of salidroside in preparation of a drug for treating or preventing a carcinoma. Researches show that the salidroside has an obvious growth inhibiting action on breast cancer cells MCF-7. The salidroside has a molecular structural formula as follows.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations containing Crassulaceae, and in particular relates to the application of salidroside in the preparation of medicines for treating or preventing cancer. Background technique [0002] Cancer is one of the major diseases that threaten human health. With the clinical application of various chemotherapy drugs, the cure rate of tumors has been significantly improved, and the survival time of patients has been significantly prolonged. The drugs currently used to treat cancer mainly include alkylating agents, antibiotics, antitumor drugs, antitumor hormones, metal platinum drugs, antimetabolites, molecular targeted drugs, and antitumor plant drugs. [0003] Alkylating agents belong to cytotoxic drugs, which combine with the protein and nucleic acid of cells to kill tumor cells, and have a direct toxic effect on cells. In addition, the chemical properties of alkylating agents are highly...

Claims

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Application Information

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IPC IPC(8): A61K31/7032A61P35/00
CPCA61K31/7032A61P35/00
Inventor 巨修练孙安琪
Owner WUHAN INSTITUTE OF TECHNOLOGY