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Screening method of traditional Chinese medicine compound quality marker

A screening method and marker technology, which is applied in the research field of marker components of traditional Chinese medicine, can solve the problems of quantitative identification, overall information of quality markers of traditional Chinese medicine, and short boards of importance ranking, so as to achieve a wide range of applications and improve the quality control level of traditional Chinese medicine , highly operable effect

Pending Publication Date: 2021-02-19
SHAANXI UNIV OF CHINESE MEDICINE
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Problems solved by technology

However, most studies only analyze and predict the effectiveness, measurability, and specificity of the chemical components of traditional Chinese medicine, but how to organically integrate these fragmented information and quantify it to obtain the overall information and quality markers of traditional Chinese medicine There are still obvious shortcomings in the ranking of importance

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  • Screening method of traditional Chinese medicine compound quality marker
  • Screening method of traditional Chinese medicine compound quality marker
  • Screening method of traditional Chinese medicine compound quality marker

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Embodiment 1

[0038] Materials and Methods

[0039] 1.1 Establishment of Qi, blood and capsule chemical composition library

[0040]Import the 15 traditional Chinese medicines DG, CS, CX, TR, HH, JG, NX, ZQ, CH, XF, WY, DS, YHS, SM, GC into the traditional Chinese medicine system pharmacology database TCMSP respectively. TM ( http: / / lsp.nwu.edu.cn / index.php ), Chinese medicine symptom association database SYMMAP( https: / / www.symmap.org / ) and TCMID ( http: / / 119.3.41.228:8000 / tcmid / ), and integrate the chemical components of the Qi, blood and prescription medicines in the three databases, namely the Qi, blood and capsule chemical composition library.

[0041] 1.2 Quantitative identification of Qi, blood and capsule quality markers based on AHP-EWM method

[0042] The AHP-EWM method was used to analyze the three core attributes of effectiveness, measurability and specificity of each component with the help of the chemical component database of Qi, blood and capsules, and the quality...

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Abstract

The invention discloses a screening method of a traditional Chinese medicine compound quality marker. The screening method comprises the following steps: (1) establishing a traditional Chinese medicine compound chemical component library; (2) quantitatively identifying the traditional Chinese medicine compound quality marker based on an analytic hierarchy process -entropy weight method; and (3) constructing a network of monarch, minister, assistant and guide properties of the traditional Chinese medicine compound quality marker. Effectiveness is taken as a core, testability and specificity aretaken as conditions, compound traditional Chinese medicines are combined with a compatibility relationship, a traditional Chinese medicine quality marker is selected and confirmed, and then functional attributes of transmission and traceability of the traditional Chinese medicine quality marker are inspected. Weight analysis is carried out by integrating an AHP method and an EWM method around three core attribute items and indexes under the items of effectiveness, testability and specificity of corresponding components of the traditional Chinese medicine, and the quality marker of the traditional Chinese medicine is comprehensively evaluated. The method is successfully applied to research of qi and blood and capsule quality markers, a new method is provided for quantitative evaluation andaccurate identification of the traditional Chinese medicine compound quality markers, and an important support is provided for powerfully improving the traditional Chinese medicine compound quality control level.

Description

technical field [0001] The invention relates to a research method for marker components of traditional Chinese medicine, in particular to a screening method for quality markers of Chinese medicine compound. Background technique [0002] Chinese medicine quality marker (Q-marker) is a new concept of Chinese medicine quality control. The concept is proposed to organically correlate the chemical components of Chinese medicine with safety and effectiveness, which has aroused the research mode of Chinese medicine quality markers in the academic and industrial circles of Chinese medicine. , methods and exemplary research has launched a wide range of academic discussions and scientific practice. However, most studies only analyze and predict the effectiveness, measurability, and specificity of the chemical components of traditional Chinese medicine, but how to organically integrate these fragmented information and quantify it to obtain the overall information and quality markers of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/10G16H20/90G16C20/50
CPCG16H20/10G16H20/90G16C20/50Y02A90/10
Inventor 唐于平黄昱曦陈艳琰乐世俊徐顶巧付瑞嘉
Owner SHAANXI UNIV OF CHINESE MEDICINE
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