A kind of gamimycin injection and preparation method thereof

A gamimycin and injection technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, medical preparations with non-active ingredients, etc., can solve the unstable pH value of products, affect product stability, and injection sites Stimulation and other issues, to achieve the effect of convenient quality control, increasing properties, and little stimulation
CN112386572BActive Publication Date: 2022-04-15AMICOGEN CHINA BIOPHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
AMICOGEN CHINA BIOPHARM CO LTD
Publication Date
2022-04-15

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Abstract

The invention discloses a gamimycin injection and a preparation method thereof. The gamimycin injection is composed of gamimycin, vitamin C and water for injection, wherein every 100ml of the solution contains 5-35 g of gamimycin , vitamin C 1~10g, all the other are water for injection; Gamithromycin injection of the present invention uses vitamin C to improve the dissolving speed of gamimycin bulk drug, has increased the solubility of gamimycin bulk drug, and vitamin C not only It has a good solubilizing effect, and also has anti-oxidation effect, which can improve the stability of the product; the gamimycin injection of the present invention is a weakly acidic aqueous phase injection, which can be used in compatibility with most drugs, greatly increasing the Gamithromycin has stable properties after long-term storage, has little irritation to the injection site, fast absorption, remarkable effect, high safety, simple prescription, convenient quality control of raw and auxiliary materials, cost saving, and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to the technical field of veterinary antibiotics, in particular to gamimycin injection and a preparation method thereof. Background technique

[0002] Gamimycin is a representative drug of the second-generation macrolide antibiotics developed by Merial, France. It inhibits bacterial RNA-dependent protein synthesis to inhibit and kill bacteria. It has a wide antibacterial spectrum and antibacterial activity. Strong, widely distributed in the body, fast absorption, low residue and high safety, etc. It is mainly used for the prevention and treatment of respiratory diseases in non-lactating cows caused by pathogenic bacteria such as Mannella hemolyticus, Pasteurella and histophilia. Veterinary clinical field has broad application prospects.

[0003] Gamimycin is a new type of semi-synthetic macrolide antibiotics. Due to its large molecular chain, its solubility in water is very poor, and it needs to be dissolved by adding a cosolvent...

Claims

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