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Reusable coaxial capillary micro-fluidic chip and preparation method thereof

A microfluidic chip and capillary technology, applied to laboratory containers, chemical instruments and methods, laboratory utensils, etc., can solve the problems of scrapped chips, inability to move, and chips that cannot produce capsules normally, and achieve high repeatability , the effect of saving time and cost

Active Publication Date: 2021-03-19
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the manufacturing process of traditional devices, the problem that the coaxial alignment of square capillaries and circular capillaries cannot be guaranteed will directly cause the chip to fail to produce capsules with a core-shell structure.
On the other hand, the existing coaxial glass capillary microfluidic chips are all disposable. When the liquid flows, if it is blocked, the liquid will not flow normally and the chip will be scrapped; It is fixed with epoxy glue and cannot be moved. During the experiment, if the relative distance between the two circular capillaries is not suitable, because the fixed distance cannot be moved to adjust the distance, it is also impossible to produce qualified core-shell structure microcapsules; At the same time, traditional chips are mostly made of fragile materials such as glass. After improvement, chips can be made of metal, polymer and other materials, which are more durable when the observation is not affected.

Method used

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  • Reusable coaxial capillary micro-fluidic chip and preparation method thereof
  • Reusable coaxial capillary micro-fluidic chip and preparation method thereof
  • Reusable coaxial capillary micro-fluidic chip and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A coaxial capillary microfluidic chip, including two circular capillaries 1 and square capillaries 2, and also includes:

[0039] The base 3 is provided with a hole as the viewing window 4. The viewing window is placed in the center of the base. The viewing window is a rectangular channel for observing the alignment of the two circular capillaries in the square capillary.

[0040] The needle platform 5 is provided with two needle platforms, and one side of the needle platform is provided with a hole 5-1 with an internal thread; the opposite side of the hole 1 is provided with a groove 5-5, and the groove is placed and fixed. Fixer 5-6 is used to fix the square capillary; the fixer is a cylinder, which matches the size of the groove; a circular groove 5-2 and a square groove are sequentially arranged between the hole 1 and the groove on the inner coaxial line of the needle platform 5-3, circular groove 1 5-2 is composed of the first circular groove 5-2-1 and the second c...

Embodiment 2

[0045] To prepare a coaxial capillary microfluidic chip, the material of the substrate used can be plastic, metal, polymer materials, etc. In this embodiment, the plastic substrate is selected, and the preparation method is as follows:

[0046] (1) Drawing printing: use drawing software to draw the base, needle alignment platform, receiver, and needle alignment device; print them out with 3D printing technology;

[0047] (2) Grinding the circular capillary: the circular borosilicate capillary is tapered to the expected diameter with a glass needle preparer, and ground into a tapered needle using a glass microelectrode (needle) grinder. The obtained tapered glass capillary was washed and dried to remove residual glass particles. Soak the capillary in 30% H 2 o 2 and 98% H 2 SO 4 solution with a ratio of 3:7, then cleaned with air and ethanol, and treated with octadecyltrimethoxysilane for 1 minute to make it hydrophobic;

[0048] (3) Installation and fixation: Fix the two ...

Embodiment 3

[0052] According to the preparation method of the present invention, the chip substrate can be prepared in batches first, and the needle alignment device, the receiver and the fixer are used for standby. When the experiment is required, the circular glass capillary is polished, and the circular capillary is placed in the square capillary according to the method in Example 2. Align the center coaxial to adjust the relative distance between the two circular capillaries for the needle and the receiver.

[0053] During use, the inverted cone connector is screwed into the two liquid inlets and the hole 3 6-3 of the needle aligner respectively, and the test is carried out after entering the liquid, and the microcapsules are obtained from one side of the circular groove 3 7-2 of the receiver.

[0054] During the experiment, when it is necessary to adjust the relative position between the two capillaries, just rotate the needle aligner and the receiver.

[0055] When the capillary is ...

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Abstract

The invention belongs to the technical field of micro-fluidic chips, and particularly relates to a reusable coaxial capillary micro-fluidic chip and a preparation method thereof. The chip comprises asubstrate, an alignment platform, a pin aligner and a receiver, wherein a hole is formed in the substrate to serve as a window; thealignment platform are fixed to the two sides of the window respectively, and first holes with internal threads are formed in one sides of the alignment platforms. A circular groove I and a square groove are sequentially formed in the coaxial line in the pin aligning platform from the hole I; two ends of the square capillary tube are respectively arranged in the square grooves of the two alignment platforms, and the receiver and the pin aligner are respectively arranged in the holes I of the two alignment platforms; one end of a circular capillary tube is fixed on the receiver, and the other end is arranged in the square capillary tube; and one end of the othercircular capillary is fixed on the pin aligner, and the other end is arranged in the square capillary. Repeated use of the coaxial glass micro-fluidic chip is realized, coaxial and accurate arrangement of the circular capillary tubes in the square tube is ensured, and the distance between the two circular capillary tubes can be adjusted at any time.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chips, in particular to a reusable coaxial capillary microfluidic chip and a preparation method thereof. Background technique [0002] Coaxial glass capillary microfluidic chip is a widely used device for producing core-shell microcapsules. Microcapsules with a core-shell structure have a wide range of applications, from the controlled release of drugs and nutrients to the rapid detection of trace liquids and molecular capture, all of which have the potential to be deeply explored. The traditional coaxial glass capillary microfluidic chip device consists of two circular capillaries with tapered heads, which are coaxially arranged in a square capillary and spaced at a certain distance from each other. In the manufacturing process of traditional devices, the coaxial alignment of the square capillary and the circular capillary is prone to occur, which will directly cause the chip to fail to pro...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/502707B01L2200/12
Inventor 陶胜洋冯时杨文博
Owner DALIAN UNIV OF TECH