Medical treatment device and method for stimulating neurons of a patient to suppress a pathologically synchronous activity thereof
A medical device and neuron technology, applied in electrotherapy, physical therapy, therapy, etc., can solve problems such as difficulty in obtaining the best stimulation results, increase in neuron strength, abnormal synchronous activity of neurons, etc.
Pending Publication Date: 2021-03-19
GRETAP AG
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Problems solved by technology
Therefore, in the absence of feedback signals from chronically implanted brain electrodes, it may be difficult to obtain optimal stimulation results with currently used stimulation modalities
[0005] It has been found that abnormally upregulated synaptic connections may lead to abnormally synchronized activity of neurons
However, repeated simultaneous activation of neurons may lead to an increase in the strength of neurons' mutual synaptic connections
Thus, in cases where repetitive and simultaneous stimulation overlaps with pathologically synchronized activity of neurons in the known non-invasive vibrotactile multichannel stimulation therapy, this treatment may even lead to the loss of pathologically synchronized activity of neurons. accidental enhancement
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[0023] Hereinafter, the present invention will be explained in more detail with reference to the accompanying drawings. In the drawings, the same elements are denoted by the same reference numerals and repeated descriptions thereof may be omitted to avoid redundancy.
[0024] figure 1 A medical device 10 for stimulating neurons of a patient to inhibit pathological synchronous activity of the neurons is schematically shown.
[0025] The medical device 10 is intended for use in the treatment of neurological or psychiatric diseases, in particular Parkinson's disease, essential tremor, dystonia, and the like. For this reason, medical device 10 may also be used to treat other neurological or psychiatric disorders, such as epilepsy, tremors caused by multiple sclerosis and other pathological tremors, depression, movement disorders, cerebellar disorders, obsessive-compulsive disorder, Tourette's syndrome syndrome, post-stroke dysfunction, spasticity, tinnitus, sleep disturbance, sc...
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The present invention pertains to a medical treatment device for stimulating neurons of a patient to suppress a pathologically synchronous activity, the device comprises at least three non-invasive stimulating units for generating stimuli to a patient's body, and a control unit for selectively and intermittently actuating the stimulating units in a sequence of actuating periods. The control unit is configured to, across the sequence of actuating periods, variedly determine for each actuating period a number n of stimulating units to be simultaneously actuated during the respective actuating period.
Description
technical field [0001] The present invention relates to a medical device and a corresponding method for stimulating neurons in a patient to inhibit pathological synchronous activity of the neurons. Background technique [0002] Several brain disorders such as Parkinson's disease are characterized by abnormally strong synchronous activity of neurons, ie strong synchronous firing or bursting of neurons. In addition to Parkinson's disease, this can also apply to, for example, essential tremor, dystonia, post-stroke dysfunction, epilepsy, depression, migraine, tension headache, obsessive-compulsive disorder, irritable bowel syndrome, chronic pain syndrome syndrome, pelvic pain, borderline dissociative personality disorder, and post-traumatic stress disorder. [0003] Pharmacological treatment of Parkinson's disease using, for example, L-DOPA may have limited efficacy and may cause significant long-term side effects. High-frequency deep brain stimulation (DBS) for Parkinson's d...
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IPC IPC(8): A61N1/04A61N1/36
CPCA61N1/0456A61N1/0476A61N1/0484A61N1/36025A61N1/36031A61N1/36034
Inventor 彼得·亚历山大·塔斯
Owner GRETAP AG