Application of SNP (single nucleotide polymorphism) in field of breast cancer chemotherapy drug resistance detection and detection kit of breast cancer chemotherapy drug resistance

A detection kit, drug resistance technology, applied in the field of biomedicine, to achieve good sensitivity effect

Active Publication Date: 2021-03-26
LANZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, there are no relevant reports on the application of SNP in the detection of drug resistance in breast cancer chemotherapy

Method used

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  • Application of SNP (single nucleotide polymorphism) in field of breast cancer chemotherapy drug resistance detection and detection kit of breast cancer chemotherapy drug resistance
  • Application of SNP (single nucleotide polymorphism) in field of breast cancer chemotherapy drug resistance detection and detection kit of breast cancer chemotherapy drug resistance
  • Application of SNP (single nucleotide polymorphism) in field of breast cancer chemotherapy drug resistance detection and detection kit of breast cancer chemotherapy drug resistance

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Embodiment Construction

[0020] Below in conjunction with specific embodiment, further illustrate the present invention. These examples are only for illustrating the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Unless otherwise defined, all professional and scientific terms used herein have the same meanings as commonly understood by those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

[0021] Materials and related reagents used in this example are as follows:

[0022] 1. Experimental materials

[0023] 1.1 Instruments used

[0024] Desktop high-speed refrigerated c...

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Abstract

The invention discloses an application of SNP (single nucleotide polymorphism) in the field of breast cancer chemotherapy drug resistance detection and a detection kit of breast cancer chemotherapy drug resistance, and belongs to the technical field of biological medicine. The SNP is an SNP locus rs9344 of a CCND1 gene and / or an SNP locus rs33954691 of a TERT gene. The detection kit of breast cancer chemotherapy drug resistance comprises a primer pair for detecting an SNP locus rs9344 of a CCND1 gene and / or an SNP locus rs33954691 of a TERT gene, and five primers for detecting the SNP locus rs9344 of the CCND1 gene are shown as SEQ ID NO.1-SEQ ID NO.5, five primers for detecting the SNP locus rs33954691 of the TERT are shown as SEQ ID NO.6-SEQ ID NO.10. The correlation of the rs9344 locuson the CCND1 gene and the rs33954691 locus on the TERT gene with breast cancer chemotherapy drug resistance is discovered for the first time, drug resistance screening is carried out during breast cancer chemotherapy, and the effects of risk early warning and early estimation can be effectively achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of SNP in the field of breast cancer chemotherapy drug resistance detection and a detection kit thereof. Background technique [0002] Breast cancer (Breast Cancer, BC) is a malignant tumor that occurs in the glandular epithelial tissue of the breast. It is the most common malignant tumor in women all over the world. Although it mainly occurs in postmenopausal women, about 25% of breast cancer patients will develop Their reproductive age is affected. In the past three decades, breast cancer has been the fifth leading cause of cancer death. According to statistics, in 2012, there were 1.66 million new breast cancer cases and 520,000 breast cancer deaths, accounting for 25.1% of breast cancer deaths and accounting for all breast cancer deaths. 14.7% of cancer deaths. Although the mortality rate of breast cancer in most countries has dropped signific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/156C12Q2600/106Y02A50/30
Inventor 谢小冬赵庆丽王静
Owner LANZHOU UNIVERSITY
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