Application of SNP (single nucleotide polymorphism) in field of breast cancer chemotherapy drug resistance detection and detection kit of breast cancer chemotherapy drug resistance

A detection kit, drug resistance technology, applied in the field of biomedicine, to achieve good sensitivity effect
CN112553336AActive Publication Date: 2021-03-26LANZHOU UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
LANZHOU UNIVERSITY
Publication Date
2021-03-26

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Abstract

The invention discloses an application of SNP (single nucleotide polymorphism) in the field of breast cancer chemotherapy drug resistance detection and a detection kit of breast cancer chemotherapy drug resistance, and belongs to the technical field of biological medicine. The SNP is an SNP locus rs9344 of a CCND1 gene and / or an SNP locus rs33954691 of a TERT gene. The detection kit of breast cancer chemotherapy drug resistance comprises a primer pair for detecting an SNP locus rs9344 of a CCND1 gene and / or an SNP locus rs33954691 of a TERT gene, and five primers for detecting the SNP locus rs9344 of the CCND1 gene are shown as SEQ ID NO.1-SEQ ID NO.5, five primers for detecting the SNP locus rs33954691 of the TERT are shown as SEQ ID NO.6-SEQ ID NO.10. The correlation of the rs9344 locuson the CCND1 gene and the rs33954691 locus on the TERT gene with breast cancer chemotherapy drug resistance is discovered for the first time, drug resistance screening is carried out during breast cancer chemotherapy, and the effects of risk early warning and early estimation can be effectively achieved.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of SNP in the field of breast cancer chemotherapy drug resistance detection and a detection kit thereof. Background technique

[0002] Breast cancer (Breast Cancer, BC) is a malignant tumor that occurs in the glandular epithelial tissue of the breast. It is the most common malignant tumor in women all over the world. Although it mainly occurs in postmenopausal women, about 25% of breast cancer patients will develop Their reproductive age is affected. In the past three decades, breast cancer has been the fifth leading cause of cancer death. According to statistics, in 2012, there were 1.66 million new breast cancer cases and 520,000 breast cancer deaths, accounting for 25.1% of breast cancer deaths and accounting for all breast cancer deaths. 14.7% of cancer deaths. Although the mortality rate of breast cancer in most countries has dropped signific...

Claims

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