Blood molecular marker for auxiliary diagnosis of hepatocellular carcinoma, primer for detecting expression level of blood molecular marker and application of blood molecular marker
A technology of molecular markers and auxiliary diagnosis, which is applied in the field of biomedical detection, can solve the problems of low diagnosis rate and threat to human life, and achieve the effect of improving the detection rate and making diagnosis convenient and easy
Inactive Publication Date: 2021-03-26
WUHAN UNIV
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Problems solved by technology
Due to the low rate of early diagnosis, HCC is often discovered at a late stage, posing a great threat to human life
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[0030] The features and advantages of the present invention can be deeply understood through the detailed description of the following embodiments combined with the accompanying drawings. The examples provided are only illustrative of the method of the present invention and do not limit the rest of the present disclosure in any way.
[0031] The experimental methods without specific conditions indicated in the following examples are conventional methods or conventional conditions well known in the art, or according to the conditions suggested by the manufacturer.
[0032] [Example] The expression level of LINC00221 in the plasma of patients with hepatocellular carcinoma is abnormally increased
[0033] 1. Subjects
[0034] EDTA anticoagulation of 83 patients with hepatocellular carcinoma, 70 patients with precancerous lesions (including patients with hepatitis B and liver cirrhosis) and 77 healthy controls were collected from September 2018 to October 2019 in Zhongnan Hospita...
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Abstract
The invention discloses a blood molecular marker for auxiliary diagnosis of hepatocellular carcinoma a primer for detecting the expression level of the blood molecular marker and an application of theblood molecular marker, and belongs to the field of biomedical detection. LINC00221 is used as an effective blood molecular marker for auxiliary diagnosis of hepatocellular carcinoma, the plasma expression level of the LINC00221 has high diagnostic value for patients with hepatocellular carcinoma, and the detection rate of the patients with hepatocellular carcinoma can be increased by combined use of the LINC00221 and plasma AFP. Besides, a kit for auxiliary diagnosis of the hepatocellular carcinoma can be prepared by utilizing the primer for detecting the expression level of the blood molecular marker for auxiliary diagnosis of hepatocellular carcinoma, and the expression level of the blood molecular marker for auxiliary diagnosis of hepatocellular carcinoma is detected, so that the diagnosis of the hepatocellular carcinoma is more convenient and feasible. The blood molecular marker is used for auxiliary diagnosis of the hepatocellular carcinoma, and the sensitivity and specificity of the blood molecular marker reach 80% or above.
Description
technical field [0001] The invention belongs to the field of biomedical detection, and in particular relates to a blood molecular marker for auxiliary diagnosis of hepatocellular carcinoma, a primer and application thereof. Background technique [0002] Primary liver cancer is a common malignant disease worldwide, its incidence rate ranks sixth among malignant tumors, and its mortality rate ranks second among cancer-related deaths. Hepatocellular carcinoma (HCC) is the main pathological type of primary liver cancer. Due to the low rate of early diagnosis, HCC is often discovered at a late stage, which poses a great threat to human life. The 5-year survival rate of HCC patients in North America is about 19%, and the 5-year survival rate of HCC patients in China is 12%. There is an urgent need for a reliable early diagnosis method for HCC. Recent studies have shown that alpha-fetoprotein (AFP), a biomarker widely used in the diagnosis of HCC, has certain shortcomings in pred...
Claims
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IPC IPC(8): C12Q1/6886C12N15/11
CPCC12Q1/6886C12Q2600/158C12Q2600/178
Inventor 涂建成冯艳林欧卡朱心雨刘雪芳伯古梁纯子
Owner WUHAN UNIV