PLT particle detection method and device for blood cell analyzer
A blood cell analysis and particle detection device technology, applied in the field of blood cell analyzers, can solve the problems that platelets are easily mistaken for red blood cells, and the accuracy of platelet detection is affected.
Active Publication Date: 2022-06-24
SHENZHEN COMEN MEDICAL INSTR
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[0004] However, some blood samples are samples containing small red blood cells or samples with red blood cell fragments. Small red blood cells and red blood cell fragments are easily detected as platelets due to their similar volume to platelets, and huge platelets are also easily mistaken for red blood cells. The histogram of the voltage pulse value-pulse number of the blood sample has no obvious features, please refer to figure 2 , figure 2 It is the histogram of the voltage pulse value-pulse number of abnormal blood samples, and the PLT-RBC boundary line is difficult to accurately distinguish platelet aggregation particles (PLT particles) from red blood cell particles (RBC particles), so that the detection accuracy of platelets is limited. great influence
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[0032] The present invention will be further described in detail below through specific embodiments in conjunction with the accompanying drawings. Wherein similar elements in different embodiments have used associated similar element numbers. In the following embodiments, many details are described so that the present application can be better understood. However, those skilled in the art will readily recognize that some of the features may be omitted under different circumstances, or may be replaced by other elements, materials, and methods. In some cases, some operations related to the present application are not shown or described in the specification, in order to avoid the core part of the present application being overwhelmed by excessive descriptions, and for those skilled in the art, these are described in detail. The relevant operations are not necessary, and they can fully understand the relevant operations according to the descriptions in the specification and gener...
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The invention discloses a method and device for detecting PLT particles of a blood cell analyzer. By classifying pulse signals according to multiple classification accuracies, the classification histograms of multiple classification accuracies are obtained, and then the classification histograms of each classification accuracies are obtained. The graph is divided into a preset number of reference sub-category histograms according to the reference boundary line, and the reference boundary line is corrected in each reference sub-category histogram to obtain an accurate sub-category histogram. Classification histogram, determine the number of platelet aggregation particles, and then determine the accurate first dividing line according to the preset display histogram function and the number of platelet aggregation particles, so that it is more accurate to distinguish between platelet aggregation particles and RBC particles.
Description
technical field [0001] The invention relates to the technical field of blood cell analyzers, in particular to a PLT particle detection method and device of a blood cell analyzer. Background technique [0002] A blood cell analyzer is an instrument that can detect cells in the blood, and can count and classify cells such as white blood cells, red blood cells, nucleated red blood cells, and reticulocytes. [0003] One of the most common methods for platelet detection in blood cell analyzers is impedance detection. The blood sample is diluted and mixed in a conductive diluent, and then the diluent flows through the holes with electrodes at both ends. When the cell particle passes through the small hole, the voltage across the small hole will generate a voltage pulse due to the change. The larger the volume of the cell particle, the larger the voltage pulse. By recording the voltage pulse value of each cell particle, it will have the same voltage pulse. The voltage pulse value ...
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IPC IPC(8): G01N15/10G01N15/02
CPCG01N15/1031G01N15/0266G01N2015/011G01N2015/018G01N2015/1029
Inventor 王兴红邹海涛
Owner SHENZHEN COMEN MEDICAL INSTR