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Group of recurrent pregnancy loss diagnosis and treatment immunomarkers and application

A marker and disease technology, applied in the field of biomedical testing, can solve problems such as the inability to evaluate the maternal immune status and the lack of specific immune markers

Inactive Publication Date: 2021-03-26
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the examination of patients with unexplained recurrent pregnancy loss mainly includes basic physical examination, ultrasonography and invasive endometrial pathological examination, which cannot evaluate the immune status of the mother, and lacks specific immune markers

Method used

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  • Group of recurrent pregnancy loss diagnosis and treatment immunomarkers and application
  • Group of recurrent pregnancy loss diagnosis and treatment immunomarkers and application
  • Group of recurrent pregnancy loss diagnosis and treatment immunomarkers and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Screening of immune cell subtypes in peripheral blood

[0024] The examples mainly include three groups of people: 50 non-pregnant women (unsuccessful group), 50 pregnant women (in group) and 50 repeated pregnancy loss women (repeated pregnancy loss group). Women in the unsourcing group and the birth group are normal, there is no history of life; women have given birth to a normal child, and there is no bad birth history between 1 to 2 years after delivery. Women who repeated pregnancy loss group occurred twice or more, the history of natural abortion or embryonic stop occurred in 20 weeks ago, and has excluded chromosomal abnormalities, abnormal uterus, and thrombosis, endocrine factors, infection and autoimmunity. disease.

[0025] EXAMPLES EXAMPLES EXAMPLES TOVERED 采 采 采 采 采 采 采 管 管 管 管 管 管 管 管 管 管 管 管 采 管 管 管 管 管 管 管 管 采 采 采 采 管

[0026] After the peripheral blood is allowed to stand, the upper plasma is absorbed, and the plasma is diluted with the PBS buffer ...

Embodiment 2

[0030] Embodiment 2 Clinical application value of differential indicators

[0031] In the examples, three groups of populations, 50 non-pregnant women (unsuccessful groups), 50 have been placed in women (in groups) and 50 patients with repeated pregnancy (repeated pregnancy loss group). Women in the unsourcing group and the birth group are normal, there is no history of life; women have given birth to a normal child, and there is no bad birth history between 1 to 2 years after delivery. Women who repeated pregnancy loss group occurred twice or more, the history of natural abortion or embryonic stop occurred in 20 weeks ago, and has excluded chromosomal abnormalities, abnormal uterus, and thrombosis, endocrine factors, infection and autoimmunity. disease.

[0032] The unsourcing group represented by non-pregnant women, as a baseline state before pregnancy of childbearing age. 95% confidence interval in 15 immunocytocytes in peripheral blood of non-pregnant women, and the same indic...

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Abstract

The invention belongs to the technical field of biomedical detection, and particularly relates to a group of recurrent pregnancy loss diagnosis and treatment immunomarkers and application. The immunomarkers comprise at least one selected from initial CD4 + T cells, central memory CD4 + T cells, effect memory CD4 + T cells, final differentiation CD4 + T cells, Treg cells, peripheral auxiliary T cells, central CD8 + T cells, final differentiation CD8 + T cells, final differentiation CD8 + T cells with non-active phase specificity, depleted CD8 + T cells, T NK cells, mature NK cells, immature NKcells, the proportion of mature NK cells / immature NK cells, and gamma delta T cells. The fifteen immune cell subtypes related to recurrent pregnancy loss prompt that the immune system of a woman withrecurrent pregnancy loss is in a state of insufficient immune tolerance, so that abortion caused by a fetus carrying a paternal antigen cannot be avoided.

Description

Technical field [0001] The present invention belongs to the field of biomedical testing, and in particular, the present invention relates to a group of repeated pregnancy loss disease diagnosis and treatment immunomodices and applications. Background technique [0002] Repeated pregnancy loss refers to the loss of pregnancy loss of 2 or more times before 20 weeks of pregnancy, and its incidence of women in childbearing age is 1% ~ 5%, and the risk of miscarriage in pregnancy again with abortion Increased increase. Its patients mainly include abnormal chromosomes, anatomical structure, endocrine factors, autoimmune factors, tendons, infections, and environment, psychology. It is a case where the clinician and patient is: about 50% of women still can't find the causes of repeated pregnancy loss after excluding the above known reasons, which is also known as unknown reasons repeated pregnancy loss. More and more studies have shown that maternal immune imbalance may be the main cause...

Claims

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Application Information

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IPC IPC(8): G01N15/14G01N33/53
CPCG01N15/14G01N33/53G01N2015/1402
Inventor 廖爱华黄晓博刘红蔺新秀尹芝南
Owner HUAZHONG UNIV OF SCI & TECH