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7-aldehyde-9-isobutyryloxy-8-hydroxythymol and application thereof in preparation of antibacterial agent or antibacterial drug

A technology of isobutyryloxy and hydroxythymol, which is applied in the field of application of 7-formyl-9-isobutyryloxy-8-hydroxythymol in the preparation of antibacterial agents or antibacterial drugs, can solve the problem of Questions to be explored

Active Publication Date: 2021-04-20
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current research on this plant shows that the phytochemical components are very rich, but the research on the antibacterial active chemical components of this plant still needs to be further studied

Method used

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  • 7-aldehyde-9-isobutyryloxy-8-hydroxythymol and application thereof in preparation of antibacterial agent or antibacterial drug
  • 7-aldehyde-9-isobutyryloxy-8-hydroxythymol and application thereof in preparation of antibacterial agent or antibacterial drug
  • 7-aldehyde-9-isobutyryloxy-8-hydroxythymol and application thereof in preparation of antibacterial agent or antibacterial drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Preparation of 7-formyl-9-isobutyryloxy-8-hydroxythymol in Eupatorium adenophorum

[0021] 1.1 Plant source and identification

[0022] A sample of the aerial part of the plant material Ageratina adenophora (Ageratina adenophora) used for extraction was collected from the suburbs of Kunming, Yunnan in July 2009, and was identified by the inventor, Dr. Tan Jianwen.

[0023] 1.2 Extraction and separation

[0024] Naturally air-dried and crushed Eupatorium adenophorum aerial parts (5kg) were used as raw materials, soaked and extracted with 95% ethanol water at room temperature for 3 times (3×10L, 24h each time). Then the ethanol extracts were combined and concentrated under reduced pressure to remove ethanol, then added an appropriate amount of water to suspend in water, extracted with petroleum ether (3×2 L), and concentrated under reduced pressure to obtain the petroleum extract (46.5 g).

[0025] The obtained petroleum ether extraction part is subjected to ...

Embodiment 2

[0033]Example 2: Detection of antibacterial activity of compound 7-formyl-9-isobutyryloxy-8-hydroxythymol

[0034] 3.1 Types of bacteria used in experiments

[0035] Gram-positive bacteria: Staphyloccocus aureus, Bacillus cereus, Bacillus thuringiensis;

[0036] Gram-negative bacteria: Escherichia coli, Salmonella enterica.

[0037] 3.2 Experimental drugs

[0038] Positive control substance: kanamycin sulfate (kanamincy sulfate)

[0039] Negative control: MeOH

[0040] Test compound: the new compound 7-formyl-9-isobutyryloxy-8-hydroxy thymol of the present invention (i.e. the following compound 1) is prepared from the above experimental examples, and two other thymols with similar structures Compound 7,9-diisobutyryloxy-8,10-dehydrothymol (ie compound 2) and 7,9-diisobutyryloxy-8-methoxythymol (ie Compound 3) is used as an active comparison reference substance for similar compounds, and the structures of compounds 1-3 are shown in the figure below:

[0041]

[0042] 3...

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PUM

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Abstract

The invention discloses 7-formyl-9-isobutyryloxy-8-hydroxythymol and an application of the 7-formyl-9-isobutyryloxy-8-hydroxythymol in preparation of an antibacterial agent or an antibacterial drug. According to the invention, the 7-aldehyde-9-isobutyryloxy-8-hydroxythymol, which has an effective inhibition effect on gram-positive bacteria and gram-negative bacteria, is extracted and separated from the ageratina adenophora plant. The ageratina adenophora plant material is rich in source and convenient to extract and prepare, the invasive plant ageratina adenophora is adopted as the raw material to be extracted, the invasive plant can be promoted to be utilized in the mode of changing waste into valuables, and the ageratina adenophora plant material is expected to have a positive promoting effect on prevention, control and treatment of ageratina adenophora indirectly while obtaining economic benefits; and the compound with the natural source is stable and easy to store. The compound 7-aldehyde-9-isobutyryloxy-8-hydroxythymol is remarkable in antibacterial activity, is very likely to be developed into an effective and safe novel antibacterial agent or developed into a novel medicine for treating bacterial infection diseases, and has a good potential prospect.

Description

Technical field: [0001] The invention belongs to the field of antibacterial, antiseptic and medical technology, and in particular relates to a novel thymol derivative compound, i.e. 7-formyl-9-isobutyryloxy-8-hydroxy thymol, and relates to the preparation of the new compound Method, and the application of the compound in the preparation of antibacterial agents or antibacterial drugs. Background technique: [0002] Pathogenic bacteria are an important source of human infectious diseases, and pathogenic bacteria are gradually accumulating resistance to existing antibacterial drugs or antibacterial preparations on the market, which is posing an increasingly significant threat to people's health. Promoting research and development of new There is an increasingly realistic and important demand for antibacterial drugs or antibacterial agents for the prevention and treatment of bacterial infection diseases. [0003] Eupatorium adenophorum is an invasive alien plant with a huge amo...

Claims

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Application Information

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IPC IPC(8): C07C69/30C07C67/56C07C67/58A61K31/222A61P31/04
CPCY02A50/30
Inventor 谭建文徐巧林刘少博钱涛
Owner SOUTH CHINA AGRI UNIV
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