Application of beraprost sodium as medicine for improving vascular dementia

A kind of beraprost sodium, vascular dementia technology, applied in the application field of medicine

Inactive Publication Date: 2021-04-23
NANJING DRUM TOWER HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no literature reporting that beraprost sodium is used in the treatment of vascular dementia.

Method used

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  • Application of beraprost sodium as medicine for improving vascular dementia
  • Application of beraprost sodium as medicine for improving vascular dementia
  • Application of beraprost sodium as medicine for improving vascular dementia

Examples

Experimental program
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preparation example Construction

[0033] Preparation of mouse vascular dementia model

[0034] Step 1: Anesthetize male B6 mice aged 8-9 weeks, about 20-25g, anesthetize the mice at 0.003ml / g chloral hydrate.

[0035] Step 2: Separation After anesthesia, the mice were fixed supine on the operating table, sheared and disinfected, and the right common carotid artery was separated by using a median incision in the neck.

[0036] Step 3: Ligation Through a median incision in the neck, the right common carotid artery is exposed and picked out of the tissue with microscopic curved forceps. Place a 7-0 silk suture around the distal end of the right common carotid artery. (Tie a slipknot, untie it after placing the spring coil and take it out).

[0037]Step 4: Coil Placement The artery is gently lifted by gripping the suture with curved forceps and the common carotid artery is placed between the coils, which are wound by rotating around the common carotid artery. The slipknot was then undone to see the common carot...

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Abstract

The invention relates to an application of beraprost sodium in preparation of a medicine for improving vascular dementia. Experiments show that the beraprost sodium can obviously improve the spatial cognitive memory ability and explore behaviors of vascular dementia mice, and the acting mechanism of the beraprost sodium is probably definitely related to the fact that oligodendrocyte precursor cells are promoted to differentiate into mature oligodendrocytes, myelin sheaths are further increased and the white matter damage effect is iimproved. The function of the beraprost sodium is primarily researched by using the modern biological technology and the bioinformatics analysis. The research shows that the beraprost sodium has a certain improvement effect on the white matter damage, and further shows that the beraprost sodium can improve the cognitive impairment of vascular dementia patients, so that the beraprost sodium can be used as a targeting drug for improving cognitive impairment of vascular dementia patients, and has potential huge application value for promoting treatment of vascular dementia. Therefore, the beraprost sodium has a good application prospect in the medicine for preventing and treating vascular dementia.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of beraprost sodium in the preparation of drugs for improving vascular dementia. Background technique [0002] With the aging of the population, neurodegenerative diseases such as Alzheimer's disease and vascular dementia are becoming more and more common, and among them, the number of patients with vascular dementia is increasing year by year, second only to Alzheimer's disease, becoming the second most common dementia disease. Vascular dementia is a spectrum of neurological deficits caused by vascular disease ranging from mild cognitive impairment to dementia. This seriously affects the health and life of human beings, especially the elderly, and brings huge spiritual and economic burdens to families and society. [0003] Vascular dementia is classified on the basis of small vessel disease with white matter changes and lacunar infarcts. After chronic cerebral hypop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5585A61K9/30A61P25/28
Inventor 徐运卞慧洁刘祎
Owner NANJING DRUM TOWER HOSPITAL
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