Buffer and preparation method for preservation of superparamagnetic particles and their protein conjugates

A buffer, superparamagnetic technology, applied in the field of protein preservation, can solve the problems of difficult magnetic particles, repeatability deviation, mixing, etc.
CN112710824BActive Publication Date: 2021-09-28SOPHONIX CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SOPHONIX CO LTD
Publication Date
2021-09-28

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Abstract

The invention belongs to the technical field of protein preservation, and in particular relates to a buffer and a preparation method for the preservation of superparamagnetic particles and their protein junctions. The buffer used for the preservation of superparamagnetic particles and their protein connectors includes the following components: disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate, sodium chloride, bovine serum albumin, sucrose, xanthan gum , sodium alginate, gelatin. The buffer provided by the present invention can store the connection between micron-sized superparamagnetic particles and superparamagnetic particles and specific proteins for a long time, so that it will not fail due to physical effects (such as sedimentation and hardening); it is a kind of Special buffer for long-term storage of superparamagnetic particles and their protein conjugates.
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Description

technical field

[0001] The invention belongs to the technical field of protein preservation, and in particular relates to a buffer and a preparation method for the preservation of superparamagnetic particles and their protein junctions. Background technique

[0002] Magnetic particle chemiluminescence is an advanced immunological detection method that can detect specific protein components in blood in vitro. This method can effectively assist doctors in assisting diagnosis of patients' conditions. Protein conjugation to micron-sized superparamagnetic particles plays an important role in this methodology.

[0003] However, the protein conjugates of superparamagnetic particles are very easy to settle and because of their poor hydrophilicity, they will gradually compact into a sheet or block structure after settling. The hardened magnetic particle-protein linker is very unstable, which will cause the overall failure of the reaction system and lead to product failure. At pres...

Claims

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