Tumor marker and application thereof
A cancer patient-responsive technology, applied in the field of tumor molecular biology, can solve problems such as poor response to neoadjuvant chemotherapy, altered cancer signal transduction, and unclear neoadjuvant chemotherapy
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[0185] Example: Verification of the response of C10orf71-related molecules to chemotherapy in patients with GC tumors
[0186] Patient Recruitment and Sample Cohorts
[0187]GC patients (>T2N+M0, UICC-AJCC 8th edition) for this inventive study were recruited at Peking University Cancer Hospital (Beijing, China) from 2015 to 2018. The study was performed in accordance with the Statement of Helsinki and was approved by the Ethics Committee of Peking University Cancer Hospital (IRB approval number, 2019KT05). All patients provided written informed consent prior to treatment, sample collection, and analysis. Tumors were collected by biopsy and matched to adjacent nontumor tissue before neoadjuvant therapy. For patients with no adjacent non-neoplastic tissue available, blood samples were taken instead. Then, all patients received a fluorouracil-based capecitabine / S-1+oxaliplatin regimen (XELOX [oxaliplatin, 130 mg / m2, intravenous injection, day 1; capecitabine, 1000mg / m2, orall...
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