4results about How to "Optimize treatment plan" patented technology

The invention discloses a xanthene nitroreductase-responsive fluorescent dye compound as well as a preparation method and application thereof, and belongs to the technical field of xanthene derivatives. The fluorescent dye compound can be used for quickly and specifically recognizing overexpressed nitroreductase in tumor cells; after the fluorescent probe acts with nitroreductase, the fluorescence intensity of the fluorescent probe at 718 nm is obviously enhanced, and the fluorescent probe has excellent targeting capability on mitochondria; meanwhile, under the excitation of illumination with the specific wavelength of 660 nm, an acting product of the fluorescent dye compound and nitroreductase can efficiently generate reactive oxygen species (ROS), and then the effect of specifically killing tumor cells is achieved. The xanthene nitroreductase response type fluorescent dye compound provided by the invention can achieve the goal of integration of diagnosis and treatment of solid tumors, and has important clinical application value.

The application discloses a feature automatic extraction method around a tooth boundary and a lesion recognition method, relates to the technical field of oral medicine, and comprises the following steps: acquiring a digital image of an oral X-ray apical film to be processed; performing automatic segmentation and contour extraction on a target tooth in the digital image of the oral X-ray apical film to obtain a tooth contour line of the target tooth; performing normalization processing on the tooth contour line; and traversing each boundary pixel point on the tooth contour line to generate an edge band feature map of the target tooth. The application can effectively extract local features highly related to lesions, especially features of a tooth boundary region, from the oral X-ray apical film, so that the recognition capability for early micro-lesions is improved.

The application provides a radiation pneumonia risk prediction method and system, which comprises the following steps: acquiring a CT image and a radiotherapy dose image, and performing rigid and non-rigid registration; adopting a piecewise linear normalization method to pretreat the registered radiotherapy dose image; adopting a CT feature extraction network to perform first feature extraction on the CT image, and simultaneously adopting an improved 3D convolution network to perform second feature extraction on the pretreated radiotherapy dose image; according to a multi-head cross attention mechanism and a position adaptive dynamic weighted fusion strategy, the first feature and the second feature are interactively modeled to obtain an interactive feature; the interactive feature is respectively delivered to a main task branch for predicting an RP risk score and an auxiliary task branch for generating a sensitivity heat map, and the RP risk score is output through the main task branch, so that more accurate and personalized RP risk assessment is realized.

This utility model relates to the field of respiratory masks, specifically a simple oxygen nebulizer mask for bronchoscopy. It includes a mask body connected to an oxygen tubing, a breathing port and a bronchoscope inlet, a connecting strap connecting the mask body to a breathing cap, an airtight plug connected to the breathing cap, the airtight plug being detachably connected to the breathing port, a connecting strip connecting the breathing cap to an inlet cap, a sealing plug connected to the inlet cap, and a detachably connected sealing plug to the bronchoscope inlet. The mask body has a sliding groove, a slider slidably connected to the side wall of the groove, a spring connected to the slider, and a sealing strip connected to the slider, which is slidably connected to the mask body. This utility model can prevent oxygen leakage from the bronchoscope inlet, ensuring the patient can continuously inhale a sufficient concentration of oxygen, maintain normal blood oxygen saturation, reduce risks during the examination, and provide basic support for the smooth conduct of the examination.