73results about How to "Optimize treatment plan" patented technology

Real-time and individualized disease monitoring is central to rapidly evolving medical sciences and technologies, but for the vast majority of patients, disease progression and treatment are monitored only in an irregular and discontinuous fashion. Consequently, disease progression and relapse are often allowed to proceed too far before they are detected, compromising the possibility of any effective treatment. For one patient, this can mean becoming refractory to the few early drug treatments that are available; for another, missing early detection may be deadly. This invention provides a method for the detection of early signals of disease and recovery thereof comprising a universal yet personalized health-monitoring solution using cell phones or other wearable smart device data that generate extensive real-time data. The invention further provides a system and method to provide answers to a variety of questions related to the patient health status and health trajectory. Its flexibility and generality is designed for a preferred application to rare disorders and rare questions for which other analytical system are lacking.

The invention provides methods of treating or preventing a condition or disorder associated with dyslipidemia with compositions comprising apolipoprotein-sphingomyelin complexes. The methods of the invention permit reduction, by 4- to 20-fold, of the amount of apolipoprotein required for therapeutic administration to bring about an ameliorative effect.

A non-invasive apparatus for rehabilitating a joint, limb, and muscles of a patient recovering from surgery on the joint, includes a continuous passive motion device having at least one support member for supporting the limb, at least one hinge coupled to the at least one support member, and at least one actuator for providing reciprocating motion of the at least one support member about the at least one hinge, a plurality of electrodes transmitting at least four modalities chosen from a group consisting of functional electrical stimulation (FES), transcutaneous electrical nerve stimulation (TENS), temperature therapy stimulation, deep vein thrombosis (DVT) prophylactic stimulation, venous blood flow monitoring, and pain monitoring, and a control unit controlling the at least one actuator and the plurality of electrodes according to a coordinated sequence of the reciprocating motion and transmission of the at least four modalities.

The present invention relates to a radiation treatment planning system and a corresponding computer program product. The system comprises means for graphically displaying an image representing a target area 10 to be treated with a set o therapeutic radiation beams and an adjacent structure comprising healthy tissue 14 and/or organs at risk 12, and for displaying corresponding dose values according to a preliminary treatment plan. The system further comprises means for allowing a user to interactively input a local dose variation, local dose variation means for revising the preliminary treatment plan such as to account for the local dose variation inputted by the user and dose recovery means comprising means for revising the treatment plan again such as to at least partially compensate for a change of dose in a predetermined recovery area caused by said dose variation.

A bone modelling and guide device comprises a one-piece cylindrical body arranged and defined by two adjacent and concentric cylindrical bearings, one external and the other internal. The external cylindrical bearing has at least two indexing features adjusting to complementary shapes formed on a band joined to a surgical guide. The internal bearing allows passage and guidance of a shaft of a drilling bit. A bottom end of the external cylindrical bearing is bevelled. The guide device can be locked in depth and in rotation during positioning of a body in the band.

The invention discloses a realizing method for a long-distance electrocardiogram monitoring system with automatic analyzing and real-time information sharing functions. The method comprises the steps that 1, automatic dynamic electrocardiogram analyzing equipment collects electrocardiogram signals and motion sensor signals and analyzes the signals in real time; 2, the automatic dynamic electrocardiogram analyzing equipment transmits analysis results in a wireless mode through a low-power-consumption Bluetooth communication module; 3, a user monitoring terminal receives data, processes the data locally in real time and the transmits the data to a long-distance monitoring terminal; 4, information received by the long-distance monitoring terminal is transmitted to a long-distance index real-time analysis processing and early warning module, and processed results are submitted to an information sharing module; 5, the information sharing module enables received information to be shared in real time according to the preset share range and the sharing mechanism. The method has the advantages that data wirelessly transmitted are reduced to the maximum degree, human intervention is reduced, high automation degree analysis is achieved, and the real-time prediction and early warning ability of severe events is improved.

The invention provides an intelligent assisted diagnosis method for children respiratory diseases and a diagnosis system thereof. The method comprises the steps of S1, acquiring assisted examination information of a to-be-diagnosed child and/or doctor interrogation diagnosis recording information; S2, according to the assisted examination information and/or doctor interrogation diagnosis recordinginformation, screening key information; and S3, according to a pre-established children disease knowledge database system, processing the key information by means of a pre-trained typical symptom diagnosis model, thereby obtaining a diagnosis result. The diagnosis result comprises at least one possible disease, and the characteristic, which corresponds with each possible disease, of the to-be-diagnosed child. The intelligent assisted diagnosis method can help non-expert doctors in improving diagnosis levels for difficult disease, thereby reducing misdiagnosis.

Disclosed herein is a device, and method for treating heart failure by electrically modulating a splanchnic nerve with an implantable device.

The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Mesothelin. In particular, the present invention relates to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy.

The invention discloses a breast cancer patient disease-free lifetime prediction model and a construction method thereof. The method builds a breast cancer patient disease-free lifetime artificial intelligence prediction model by employing an artificial intelligence machine learning algorithm based on the magnetic resonance image data and clinical feature data of a breast cancer patient, and can make early breast cancer patients effectively divided into a high-risk group and a low-risk group. The prediction model has the advantages of accuracy, simplicity, convenience, noninvasiveness and thelike, can effectively evaluate the postoperative disease-free lifetime of early breast cancer patients, is helpful for assisting clinicians to optimize treatment schemes, strengthens treatment intervention on high-risk patients as soon as possible, reduces recurrence risks of the patients, and has important guiding significance for guiding clinical treatment strategies and enhancing clinical treatment intervention and subsequent individualized follow-up visits.

The invention relates to an intelligent wearable monitoring system based on a flexible fabric sensor and a monitoring method; the intelligent wearable monitoring system comprises the flexible fabric sensor, a simulation glove, a data acquisition circuit, a controller and a PC (personal computer); the flexible fabric sensor is a resistive flexible knit strain sensor and is bonded to each finger in the simulation glove through high-elasticity hot-melt film, a data acquisition control device composed of the data acquisition circuit and the controller is packaged in a releasable insulating box and is fixed at the outer side of the simulation glove, a lead of the flexible fabric sensor is connected to the acquisition input end of the data acquisition control device fixed at the outer side of the simulation glove, the output end of the data acquisition control device is connected to the input end of a storage through a USB (universal serial bus) cord, the output end of the storage is connected to the PC, and the PC is one in which a rehabilitation training estimation system is installed. The intelligent wearable monitoring system and the monitoring method can provide more accurate real-time monitoring and can also provide remote monitoring, such that time is saved for patients and physicians.

The invention discloses a management system and a method for respiratory drug administration information. The system comprises a respiratory drug administration device and an individual data management terminal, wherein the respiratory drug administration device comprises a drug container, a drug release switch, a drug administration channel, a drug administration information acquisition module and a wireless communication module; the drug administration information acquisition module is electrically connected with the wireless communication module; the system also comprises a cloud big data management platform and a medical monitoring platform. By means of the system and the method, high-quality big data can be established to serve as medical research support, the quantization reference standard is provided for patients and medical workers, and research on disease treatment is promoted; medical workers can master the medication condition and the treatment effect of the patients to improve treatment schemes; the patients can conveniently and scientifically adjust the drug administration scheme and can know the recovery effect of diseases.

The invention discloses a Kelarmycin dry suspensoid and its preparing process consisting of, subjecting the Kelarmycin to twice granulation, i.e. mixing with a quantitative of binding agent, granulation and drying, coating a film dressing layer to the obtained particles with macromolecular dressing material, mixing auxiliary materials including suspension aid, bulking agent, flavoring agent, acid and alkali conditioning agent, forming pellets, and mixing with dressing particles.

Described herein are nanoparticle conjugates that demonstrate enhanced penetration of tumor tissue (e.g., brain tumor tissue) and diffusion within the tumor interstitium, e.g., for treatment of cancer. Further described are methods of targeting tumor-associated macrophages, microglia, and/or other cells in a tumor microenvironment using such nanoparticle conjugates. Moreover, diagnostic, therapeutic, and theranostic (diagnostic and therapeutic) platforms featuring such nanoparticle conjugates are described for treating targets in both the tumor and surrounding microenvironment, thereby enhancing efficacy of cancer treatment. Use of the nanoparticle conjugates described herein with other conventional therapies, including chemotherapy, radiotherapy, immunotherapy, and the like, is also envisaged.

A method for planning an infusion into hepatic tissue into a patient includes: obtaining anatomical and/or physiological patient data of the patient's liver or a region of the liver; determining at least one patient parameter from the patient data; planning the infusion using the anatomical patient data, physiological patient data, and/or at least one patient parameter, wherein planning includes determining how an administered substance is distributed in the tissue and/or how the administered substance influences physiological properties of the tissue; and determining a distribution and/or effectiveness of a therapeutic agent administered with the substance or after the substance.

A slowly-releasing composite medicine for treating the diseases in respiratory system is prepared from Fuduositan (15-30 Wt %), clarithromycin (10-40), and auxiliary (rest) including paralyser.

Tetrahydroberberine (THB), isolated from the Chinese herb “Corydalis ambigua”, exhibits a variety of pharmacological effects, although mechanisms of action are unclear or entirely unknown. Described herein are novel methods of using tetrahydroberberine (THB), THB analogs or derivatives, tetrahydroprotoberberines (THPB). Tetrahydroberberine (THB) and analogs such as l-stepholidine (l-SPD) potently block functional KATP channels natively expressed on midbrain dopamine neurons. Further, THB also blocks pancreatic β-cell KATP channels, and can be developed to a novel drugs for treating disease and/or conditions such as diabetes and Parkinson's disease.