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A kind of preparation method of cation-induced self-assembly positively charged gold nanoparticle material

A gold nanoparticle, nanoparticle technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problem of low nanoparticle uptake efficiency, and achieve the effect of increasing uptake and reducing toxic and side effects

Active Publication Date: 2022-01-04
SHANDONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In general, the surface of the cell membrane has a weak negative charge, which will repel anionic nanoparticles into the cell, resulting in a lower efficiency of the uptake of these nanoparticles by the cell

Method used

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  • A kind of preparation method of cation-induced self-assembly positively charged gold nanoparticle material
  • A kind of preparation method of cation-induced self-assembly positively charged gold nanoparticle material
  • A kind of preparation method of cation-induced self-assembly positively charged gold nanoparticle material

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Embodiment approach

[0053] The third embodiment of the present invention provides an application of the above-mentioned self-assembled positively charged gold nanoparticle material in bioimaging preparations or tumor treatment drugs.

[0054] Specifically, the application in the delivery carrier of tumor therapy drugs.

[0055] In order to enable those skilled in the art to understand the technical solution of the present invention more clearly, the technical solution of the present invention will be described in detail below in conjunction with specific embodiments.

Embodiment 1

[0057] A method for preparing positively charged self-assembled gold nanoparticles induced by cations, comprising the steps of:

[0058] (1) Under the condition of 37 ℃ temperature and strong stirring (1000rpm), 10mL 10mM tetrachloroauric acid aqueous solution is quickly added in 10mL 50mg / mL bovine serum albumin aqueous solution, after stabilizing for 2 minutes, add 1mL 1M sodium hydroxide aqueous solution, Adjust the pH of the solution to pH=12. Raise the temperature to 70°C and keep it warm for 60min under the condition of strong stirring (1000rpm). The solution color changed from bright yellow to light brown, and finally to dark brown, indicating the formation of gold nanoclusters. Use a dialysis bag (MWCO=14000Da) to completely dialyze the gold nanocluster solution in ultrapure water for 48h, and replace the ultrapure water every 4h to remove excess unreacted tetrachloroauric acid and sodium hydroxide to obtain gold nanoclusters Clusters (referred to as Au-NCs) in aqueo...

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Abstract

The invention discloses a method for preparing a cation-induced self-assembly positively charged gold nanoparticle material. The gold nanoclusters are prepared by using bovine serum albumin as a stabilizer, and the aqueous solution of the gold nanoclusters is mixed with ethylenediamine-hydrochloric acid solution, and then Add 1‑(3‑dimethylaminopropyl)‑3‑ethylcarbodiimide hydrochloride, stir and stabilize to obtain a self-assembled positively charged gold nanoparticle material. The gold nanoparticle material provided by the invention inherits the properties of gold nanoclusters similar to small molecules, and exhibits an aggregation-induced luminescent effect.

Description

technical field [0001] The invention relates to the technical field of preparation of self-assembled materials, and relates to a method for preparing a cation-induced self-assembled positively charged gold nanoparticle material. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] As an emerging nanotechnology, self-assembly technology can prepare larger-sized nanoparticles, meet the requirements of passive targeting, and reduce the toxic and side effects on normal cells or tissues. Gold nanoparticles prepared by self-assembly nanotechnology are expected to become drug delivery carriers that adapt to the tumor microenvironment and have targeting effects. [0004] Electrostati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K47/02A61K47/42A61K9/14A61K45/00A61P35/00B82Y5/00
CPCA61K49/0019A61K49/0056A61K49/0093A61K47/02A61K47/42B82Y5/00
Inventor 蒋妍彦杨晶晶王凤龙李辉
Owner SHANDONG UNIV
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