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Application of p276-00 in preparation of medicine for preventing and treating noise-induced hearing loss

A hearing loss and noise technology, applied in the field of medicine, can solve the problem of scarcity of drugs for noise-induced hearing loss

Active Publication Date: 2021-06-08
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention aims at the scarcity of existing medicines for preventing and treating noise-induced hearing loss, and aims to provide the application of Riviciclib hydrochloride (p276-00) in the preparation of medicines for preventing and treating noise-induced hearing loss

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  • Application of p276-00 in preparation of medicine for preventing and treating noise-induced hearing loss

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Embodiment Construction

[0033] The technical solutions of the present invention will be further described below in conjunction with the drawings and embodiments.

[0034] After research, we found that the changes in gene expression after noise exposure were mainly enriched in the "cell cycle signaling pathway". Through qPCR verification, we found that the expression of CDK1 and Cyclin B were up-regulated after noise exposure. Therefore, it was inferred that noise-induced hearing loss is related to the activation of CDK1.

[0035] Riviciclib hydrochloride (p276-00) is a CDK1, 4, 9 inhibitor, so the present invention provides a new application of Riviciclib hydrochloride (p276-00), that is, Riviciclib hydrochloride (p276-00) is used in the preparation and prevention of noise-induced hearing loss Loss of drug use.

[0036] Riviciclib hydrochloride (p276-00) of the present invention can be used alone when preparing the medicine for preventing and treating noise-induced hearing loss; it can also be used ...

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Abstract

The invention discloses an application of Riviciclib hydrochloride (p276-00) in preparation of a medicine for preventing and treating noise induced hearing loss, relates to the field of medicines, and aims to solve the problem that existing medicines for preventing and treating noise induced hearing loss are rare. According to the invention, with the application of the noise induced hearing loss animal model experiment method, the hearing, the internal hair cell function and the like of the mouse after the noise exposure are detected, it is found that the Riviciclib hydrochloride (p276-00) has the good protection effect on the number and the function of the internal hair cell synapses during the noise exposure, the prevention and treatment effect of the Riviciclib hydrochloride (p276-00) on the noise induced hearing loss is directly verified, and the Riviciclib hydrochloride (p276-00) can be used for preparing the medicines for preventing and treating the noise induced hearing loss and has good research and application prospects.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the new application of Riviciclib hydrochloride (p276-00), and more specifically, to the application of Riviciclib hydrochloride (p276-00) in the preparation of medicines for preventing and treating noise-induced hearing loss. Background technique [0002] Noise-induced deafness is one of the most common acquired sensorineural hearing loss. At present, more than 12% of the world's population is at risk of noise-induced hearing loss. As exposure to traffic noise and entertainment noise becomes more and more common in daily life, the ribbon synapse damage between the inner hair cells and the afferent nerve often has an insidious onset after noise exposure, which will not only accelerate the occurrence of presbycusis, but also Increased risk of dementia has become a serious potential health threat, resulting in serious social problems and economic burden. The damage of inner hair cell ribbo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4025A61P27/16
CPCA61K31/4025A61P27/16
Inventor 吴皓刘辉辉
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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