New uses for nucleotides

A technology of nucleotides and single nucleotides, applied in the field of new uses of nucleotides, can solve the problems of curing, not changing the course of allergic diseases, and easy relapse of the disease

Active Publication Date: 2021-12-14
陈玉松
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most important treatment for allergic diseases is chemical drug therapy. Although it can alleviate the disease to a certain extent, drug treatment cannot change the process of allergic diseases, and there is no long-term sustained drug effect after stopping the drug. Relapse, and long-term use of chemical drugs may have a negative impact on the body, so it cannot fundamentally achieve the effect of cure

Method used

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  • New uses for nucleotides
  • New uses for nucleotides
  • New uses for nucleotides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 1. The nucleotides in this example are mixed in the form of five 5' mononucleotides or their sodium salts according to: CMP43%, AMP17%, UMP21%, GMP18%, IMP1%.

[0021] 2. The specific preparation method is as follows:

[0022] (1) Detect the five 5' mononucleotides or their sodium salts respectively, and reserve them after passing the test.

[0023] (2) Pass the five kinds of 5' mononucleotides or their sodium salts that have passed the quality inspection through a 60-mesh sieve for use.

[0024] (3) Calculate and weigh the required amount of each single nucleotide sample according to the proportion, add all the samples and mix them together, and the mixing time is not less than 40 minutes. The obtained samples were stored at room temperature.

Embodiment 2

[0026] The nucleotides in this example are mixed in the form of five 5' mononucleotides or their sodium salts according to the ratio: CMP78%, AMP6%, UMP8%, GMP7%, and IMP1%. The preparation method is the same as in Example 1.

Embodiment 3

[0028] Nucleotides in this example are mixed in the form of five 5' mononucleotides or their sodium salts according to the ratio: CMP23%, AMP44%, UMP25%, GMP7%, and IMP1%. The preparation method is the same as in Example 1.

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Abstract

The invention discloses a new use of nucleotide and its use in preparing medicines for preventing and treating diseases such as allergic rhinitis or functional food for alleviating symptoms of allergic rhinitis. Nucleotides are a mixture of five nucleotides: CMP, AMP, UMP, GMP, and IMP. Nucleotides have a small molecular weight, can be absorbed by the human body quickly and have high bioavailability. The present invention finds that the intake of nucleotides can alleviate the symptoms of allergic rhinitis in mice, alleviate the splenomegaly caused by allergy, significantly reduce the level of histamine in serum and nasal lavage fluid, and effectively regulate inflammatory factors, thereby treating allergies effect of disease. It can be used to prepare drugs for preventing and treating allergic rhinitis and other diseases or functional food for alleviating symptoms of allergic rhinitis, and provides a new way for dietary intervention to regulate immune function.

Description

technical field [0001] The invention relates to the technical field of drug development and the technical field of functional food, in particular to the new application of nucleotides. Background technique [0002] Allergic diseases refer to a class of diseases in which the body produces a large number of antibodies after contact with one or more sensitizing substances (allergens), thereby causing tissue or organ dysfunction or damage, which mainly includes allergic rhinitis, asthma, atopic Dermatitis, allergic gastrointestinal disease and food allergy. Allergic diseases have become a common public health problem, and the incidence is increasing year by year, causing a huge medical burden on patients. At present, the most important treatment for allergic diseases is chemical drug therapy. Although it can alleviate the disease to a certain extent, drug treatment cannot change the process of allergic diseases, and there is no long-term sustained drug effect after stopping the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7072A61K31/708A61K31/7068A61K31/7076A61P11/02A61P37/08A23L33/13A23L2/52A23C9/16A23C9/152A21D13/06
CPCA61K31/7072A61K31/708A61K31/7068A61K31/7076A61P11/02A61P37/08A23L33/13A23L2/52A23C9/16A23C9/1526A21D13/06A23V2002/00A61K2300/00A23V2200/304C12N15/117C12N2310/17
Inventor 李勇刘欣然徐美虹陈玉松曾峥
Owner 陈玉松
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