Application of USP10 in hepatic ischemia reperfusion injury

A technology of reperfusion injury, 1.USP10, applied in the field of biomedicine, can solve the problem that the pathophysiological effect has not been fully confirmed, and achieve the effect of reducing liver ischemia-reperfusion injury

Inactive Publication Date: 2021-06-11
WUHAN UNIV
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However, the pathophysiological role of USP10 in liv

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  • Application of USP10 in hepatic ischemia reperfusion injury
  • Application of USP10 in hepatic ischemia reperfusion injury
  • Application of USP10 in hepatic ischemia reperfusion injury

Examples

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[0076] Below in conjunction with specific embodiment. To further set forth the present invention, it should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of protection of the present invention. The specific experimental conditions and methods not indicated in the following examples are usually according to conventional conditions such as: U.S. National The conditions described in the Guide for the Care and Use of Laboratory Animals of the Institute of Health; D.L. Spector et al., Science Press, 2001, Guidelines for Cell Experiments, etc., or as recommended by the manufacturer.

[0077] 1. Animal models and procedures

[0078] USP10 knockout mice (USP10-HZ) and C57BL / 6 wild-type mice (WT mice) (male, 8 weeks old, body weight: 25-27 g) were obtained from the Animal Experiment Center of Wuhan University. We performed experiments in accordance with the Guide for the Care and Use of Laboratory Animals of...

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Abstract

The invention discloses an application of USP10 in hepatic ischemia reperfusion injury. A USP10 gene knockout mouse and a C57BL/6 wild type mouse are selected as experimental subjects, mouse hepatic ischemia reperfusion injury models are constructed respectively, the function of USP10 in hepatic ischemia reperfusion injury is researched, the new function of the USP10 gene in hepatic ischemia reperfusion injury is found, and the application of the USP10 gene in hepatic ischemia reperfusion injury is developed. The over-expression of the USP10 can relieve the hepatic ischemia reperfusion injury by inhibiting inflammation and cell apoptosis, so that the USP10 can be applied to the preparation of the medicine for preventing/treating the hepatic ischemia reperfusion injury, and a new medicine target is provided for the hepatic ischemia reperfusion injury.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of USP10 in liver ischemia-reperfusion injury. Background technique [0002] Liver ischemia-reperfusion injury (I / R) injury is a common pathophysiological process during liver transplantation. I / R injury often leads to hepatic insufficiency or even irreversible liver injury, which is also the main reason for acute and chronic rejection of liver transplantation. Because marginal donor livers are very sensitive to ischemic injury, I / R injury also limits the use of marginal donor livers. During liver ischemia, danger-associated molecular patterns (DAMPs) activate Kupffer cells, neutrophils, and other immune cells, which then release inflammatory cytokines and chemokines. A series of inflammatory responses are activated, leading to further apoptosis and necrosis of liver cells. Therefore, inflammatory response and apoptosis are key steps in liver I / R injury, ...

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Application Information

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IPC IPC(8): A61K45/00A61P1/16A61P9/10
CPCA61K45/00A61P1/16A61P9/10
Inventor 周江桥邱涛王天宇陈忠宝马枭雄张龙邹寄林
Owner WUHAN UNIV
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