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Extracellular vesicles derived from mesenchymal stem cells

A technology of stem cells and cells, applied in the field of preparing these EVs, can solve the problems that have not been raised

Pending Publication Date: 2021-06-11
HEALTH & BIOTECH FRANCE (H & B FRANCE) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0034] More generally, none of the prior art literature has suggested treating MSCs with IL4, let alone improving their pro-angiogenic properties

Method used

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  • Extracellular vesicles derived from mesenchymal stem cells
  • Extracellular vesicles derived from mesenchymal stem cells
  • Extracellular vesicles derived from mesenchymal stem cells

Examples

Experimental program
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Embodiment

[0172] The present invention has been described by reference to exemplary embodiments of the invention, for purposes of simplicity and illustration. It will be apparent, however, to one of ordinary skill in the art that the present invention may be practiced without limitation to these specific details. In other instances, well known methods have not been described in detail so as not to unnecessarily obscure the present invention.

[0173] All steps 1 to 4 below were performed as described in the Examples section of PCT / EP2017 / 082316 (which is hereby incorporated by reference).

[0174] 1. Isolation of Mesenchymal Stem Cells (MSCs) Obtained from Pro-Angiogenic Umbilical Cords

[0175] The umbilical cord was removed from the shipping solution and cut into 2 to 3 cm long sections. To avoid contamination by adherent blood cells, each segment containing an irremovable clot will be discarded. The sections were then placed in a bath of antibiotics and antifungals (composed of αMEM...

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Abstract

The present invention discloses a composition comprising extracellular vesicles (EVs) of placenta tissue derived CD106high CD151+Nestin+mesenchymal stem cells (MSCs). In a first aspect, the invention relates to a particular method to prepare these EVs. In a second aspect, the invention relates to a therapeutic, a diagnostic, a veterinary or a cosmetic composition comprising the extracellular vesicles (EVs)obtained by said particular method. In a third aspect, the invention relates to a composition comprising these EVs, for use as a medicament for treating subjects suffering from an ischemic disease, a disorder of the circulatory system, an immune disease, an organ injury or an organ function failure.

Description

technical field [0001] Summary [0002] The invention discloses a composition comprising CD106 derived from placental tissue 高 CD151 + Nestin + Extracellular vesicles (EVs) of mesenchymal stem cells (MSCs). [0003] In a first aspect, the invention relates to a specific method for the preparation of these EVs. [0004] In a second aspect, the present invention relates to a therapeutic, diagnostic, veterinary or cosmetic composition comprising extracellular vesicles (EVs) obtained by said specific method. [0005] In a third aspect, the present invention relates to compositions comprising these EVs for use as a medicament for the treatment of a subject suffering from an ischemic disease, a circulatory disorder, an immune disease, an organ injury or organ failure. Background technique [0006] The therapeutic potential of mesenchymal stem cells (MSCs) for repairing and regenerating damaged tissues has been extensively studied in both preclinical and clinical stages. MSCs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/0775
CPCC12N5/0665C12N2501/165C12N2501/2301C12N2501/2304C12N2502/115A61K35/28A61P3/10A61P7/06A61K8/981A61Q19/00C12N2501/10
Inventor A·德弗兰西斯科韩忠朝
Owner HEALTH & BIOTECH FRANCE (H & B FRANCE)