An intracerebral microdialysis recording device for awake, freely moving animals

Abstract

A microdialysis recording device for conscious, free-moving animals in the brain, which includes an animal activity structure and a placement structure for placing the animal activity structure; above the animal activity structure, a device for accommodating fixed pipelines on the animal is provided. The trajectory control structure, the trajectory control structure and the placement structure are flexibly connected through the connection structure; the trajectory control structure includes a swivel for fixing the probe plastic tube and a fixed structure for connecting animals arranged at the lower end of the swivel; in this way, When the animal moves inside the animal activity structure, the pipeline fixed in the track control structure and located on the animal can rotate following the movement of the animal, and the pipelines will not be entangled or knotted. The invention can effectively save the production cost, and has the advantages of convenient operation and strong practicability.

Description

technical field [0001] The invention belongs to the field of experimental equipment, and in particular relates to a microdialysis recording device in the brain of an animal used for awake and free movement. Background technique [0002] Intracerebral microdialysis experiments in rodents are experiments that measure the secretion of chemical substances in specific locations in the brain of the central nervous system. Firstly, a microdialysis probe is embedded in a specific position in the brain of the animal through surgery: the probe contains a semi-permeable membrane, which is divided into pipelines in two directions of inflow and outflow, and the liquid can be pumped into the inflow end and collected into the brain at the outflow end Chemical substances secreted by the recording site (components such as neurotransmitters). In the experimental recording, the liquid (artificial cerebrospinal fluid) was slowly pumped into the probe inflow line, and the outflow fluid in the p...

AI Technical Summary

Problems solved by technology

[0003] At present, the microdialysis products in the brain of animals used for conscious and free movement are common foreign products, which have the following shortcomings: 1. The existing commercialized animal activity structure is square, which restricts the free movement of animals; 2. The center of gravity of some devices is on one side, resulting in unstable placement of the device and easy damage to the structure; 3. The entire set of equipment used in specific use is foreign products, expensive, and there are many inconveniences in the process of purchase and use, such as the progress of import routes Limiting factors such as slowness, high prices of imported goods, difficulty in accessories and maintenance, and difficulty in offline technical support

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