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Composition for relieving itching, soothing and strengthening skin barrier as well as preparation and application of composition

A skin barrier and composition technology, applied in the field of daily chemicals, can solve the problems of weak anti-sensitivity and strengthening skin barrier function, poor antipruritic effect, etc., so as to relieve skin itching, inhibit skin itching, and improve skin allergies Effect

Pending Publication Date: 2021-06-18
COSMAX CHINA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the defects of poor antipruritic effect, weak anti-sensitivity and weak skin barrier function in the prior art, this application selects Radix Radix Radix Radix Radix Radixe Radix, Cnidiac Fructus Extract, Hemp Leaf Extract as effective antipruritic relief, improving skin allergy, skin Compositions for problems such as barrier fragility

Method used

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  • Composition for relieving itching, soothing and strengthening skin barrier as well as preparation and application of composition
  • Composition for relieving itching, soothing and strengthening skin barrier as well as preparation and application of composition
  • Composition for relieving itching, soothing and strengthening skin barrier as well as preparation and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0031] Example: Preparation of Antipruritic and Soothing Composition

[0032] In the following examples and comparative examples of the present invention, the antipruritic and soothing composition is prepared by the following process.

[0033] (1) Pulverize the plant raw materials respectively, dry them, pass through a 60-mesh sieve, weigh them according to the proportioning ratio, and mix them evenly;

[0034] (2) adding ethanol for extraction, the mass ratio of the crude drug to ethanol (80% mass fraction) is 1:20, the extraction temperature is 50°C, the microwave is 7min, the ultrasonic time is 40min, and the extraction times is 2 times;

[0035] (3) cooling the extract obtained in step (2) to 25° C., filtering with 200 mesh gauze to obtain the initial filtrate;

[0036] (4) centrifuging the primary filtrate obtained in step (3) for 30min, the rotating speed is 6000rpm with a microfiltration membrane with a pore size of 0.5 μm to filter, collect the filtrate, and obtain th...

experiment example 1

[0046] Experimental example 1: In vitro inhibition test of hyaluronidase

[0047] Compositions 1 to 15 and the antipruritic and soothing compositions of Comparative Examples 1 to 3 were respectively prepared into aqueous solutions with a mass fraction of 1% as sample liquids.

[0048] Add 0.1mL 0.25mmol / L CaCl to the test tube 2 Solution and 0.5mL hyaluronidase solution, incubated at 37°C for 20min; added 0.5mL sample solution, incubated at 37°C for 20min; added 0.5mL sodium hyaluronate solution, incubated at 37°C for 30min; mol / L NAOH solution 0.1ml and acetylacetone solution 0.5ml, heat reaction in boiling water bath for 15min, then ice bath for 5min; then add 1.0mL Erlich reagent and dilute with 3.0mL absolute ethanol, let stand for 20min for color development , measure its absorbance value, and substitute it into the following formula to calculate the inhibition rate.

[0049] Hyaluronidase inhibition rate (%)=[(A-B)-(C-D)] / (A-B)*100%

[0050] In the formula: A is the a...

experiment example 2

[0056] Experimental Example 2: Safety Patch Test

[0057] Add 20 μL of the liquid to be tested dropwise to the spot tester, and the control hole is the blank control (pure water); stick the spot tester with the test substance on the flexion side of the forearm of the subject, and press lightly with the palm to make it evenly Stick it on the skin and last for 24 hours; observe the skin irritation and sensitization according to Table 2 after 30 minutes, 24 hours, and 48 hours after removing the test object spot tester, and record the observation results.

[0058] Table 3 shows the skin reaction grading standards of the skin-closed patch test.

[0059] table 3

[0060]

[0061] Experimental results: Compositions 8, 13, and 15 were formulated into 2% aqueous solutions for human skin patch testing, and the results are shown in Table 4. The results of human skin patch test showed that there were no skin adverse reactions in 20 people.

[0062] Table 4

[0063]

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Abstract

The invention discloses a composition for relieving itching, soothing and strengthening a skin barrier as well as preparation and application of the composition. According to the composition, a radix saposhnikoviae extract, a fructus cnidii extract and a cannabis sativa leaf extract are selected as components for effectively relieving itching, soothing and improving problems of skin allergy, skin barrier fragility and the like. The composition can effectively relieve skin itch, prevent skin allergy and strengthen skin barrier. The radix saposhnikoviae, the fructus cnidii and the cannabis sativa leaves are all natural herbal medicines, can inhibit skin itching feeling in a multi-channel mode, are synergistic, green and safe, and can effectively relieve itching, relieve and improve problems of skin allergy, skin barrier fragility and the like through scientific proportioning.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and relates to a composition for relieving itching and strengthening skin barrier and its preparation and application, especially the application in cosmetics. Background technique [0002] Itching is an unpleasant feeling that triggers the desire to scratch the body. Skin itching has always been a common skin problem that plagues people, affecting people's daily life and quality of life. itch, but is less effective for non-histamine-dependent itch, such as dry skin pruritic itch due to disruption of the skin barrier. And it has no obvious effect on anti-sensitivity and strengthening the skin barrier. Contents of the invention [0003] In order to overcome the defects of poor antipruritic effect, weak anti-sensitivity and weak skin barrier function in the prior art, this application selects Radix Radix Radix Radix Radix Radixe Radix, Cnidiac Fructus Extract, Hemp Leaf Extract as effective antipr...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61P17/04A61P37/08
CPCA61K8/9789A61Q19/00A61Q19/005A61P17/04A61P37/08A61K2800/5922A61K2800/82A61K2800/81A61K2800/782
Inventor 马艺宸周秋娜金荣熙陈欢尹锺赫金延埈
Owner COSMAX CHINA INC
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