Hierarchical porous bone repair bioscaffold material with photothermal effect and preparation method
A bio-scaffold, photothermal effect technology, used in drug delivery, tissue regeneration, pharmaceutical formulations, etc., can solve problems such as side effects, local recurrence of drug resistance, and achieve efficient conversion and promote bone tissue regeneration.
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Embodiment 1
[0033] Step 1: Add 20mL deionized water to a 50mL round bottom flask with a stirrer, then add 1g silk fibroin powder, 0.5g bacterial cellulose dispersion (BC) and 20mg MXene powder, stir at room temperature and Dissolving; then the solution was stirred rapidly for 15 min at a speed of 3000 rpm to obtain a uniformly sized and uniformly distributed bubble dispersion.
[0034] Step 2: Pour the treated solution into a cylindrical plastic mold and place it in a water bath at 60° C. for 3.5 hours to obtain a gel material; finally freeze-dry the gel material to obtain a hierarchical porous scaffold material.
Embodiment 2
[0036] Step 1: Add 20mL deionized water to a 50mL round bottom flask with a stirring bar, then add 1g silk fibroin powder, 0.5g bacterial cellulose dispersion liquid and 20mg MXene powder, stir and dissolve at room temperature ; Then add 50 μL of 25% ammonia solution to adjust the pH to 10, and then stir the solution at a speed of 3000 rpm for 15 minutes to obtain a uniformly sized and uniformly distributed bubble dispersion.
[0037] Step 2: Pour the treated solution into a cylindrical plastic mold and place it in a water bath at 60° C. for 3.5 hours to obtain a gel material.
[0038] Step 3: Take out the gel material and place it in an aqueous solution of ammonium sulfate with a concentration of 200 g / L for soaking and cross-linking for 24 hours, and then lyophilize the cross-linked gel to obtain a scaffold material.
Embodiment 3
[0040] Step 1: Add 20mL of deionized water to a 50mL round bottom flask with a stirrer, then add 1g of silk fibroin powder, 0.5g of bacterial cellulose dispersion and 20mg of GO powder, stir and dissolve at room temperature ; Then add 50 μL of 25% ammonia solution to adjust the pH to 10, and then stir the solution at a speed of 3000 rpm for 15 minutes to obtain a uniformly sized and uniformly distributed bubble dispersion.
[0041] Step 2: Pour the treated solution into a cylindrical plastic mold and place it in a water bath at 60° C. for 3.5 hours to obtain a gel material.
[0042] Step 3: Take out the gel material and place it in 200 g / L ammonium sulfate aqueous solution to soak and cross-link for 24 hours, and then freeze-dry the cross-linked gel to obtain the scaffold material.
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