Dynamic function connection research method for teenager myoclonus epilepsy and application

Abstract

The invention provides a dynamic function connection research method for teenager myoclonus epilepsy and application, and belongs to the field of information processing of medical or health data and images. The method comprises the following steps: (1) data acquisition; (2) data preprocessing; (3) dynamic function connection construction; and (4) data analysis. According to the invention, the change of the brain function of a JME patient is explored through a dynamic function connection research method constructed through a sliding window method, so that the time resolution is improved, the shortages of nuclear magnetic resonance imaging in the time dimension are made up to a certain extent, the function connection matrix is clustered on the basis, the generality existing in the correlativity of the brain areas of the patient is found out, a basis based on iconography analysis is provided for discovering the origin of the JME, and the obtained conclusion is consistent with the research of previous people on the disease so as to help to find the core brain area causing the disorder of the brain function network of the juvenile muscular spasmodic epilepsy patient and facilitate the early discovery, early diagnosis and early treatment of the patient.

Description

technical field [0001] The invention belongs to the field of information processing of medical or health data and images, and in particular relates to a research method of dynamic functional connectivity constructed by a sliding window method to explore changes in brain function of juvenile myoclonic epilepsy patients. Background technique [0002] Juvenile myoclonic epilepsy (JME) is a common and important idiopathic generalized epilepsy syndrome. The main clinical manifestations are myoclonic seizures, absence seizures, and generalized tonic-clonic seizures. The three types of seizures appear in different age groups. The main feature of the onset is myoclonic seizures during the awakening period, which occurs 30 minutes to 1 hour after awakening. , The consciousness is clear during the attack, showing electric shock-like, irregular, and arhythmic myoclonic jerks, mostly involving the bilateral upper limbs and shoulders, and occasionally involving the lower limbs, trunk or ...

AI Technical Summary

Problems solved by technology

Among adults and adolescents with epilepsy, the highest prevalence rate is 10%, with high genetic susceptibility, the age of onset is between 8 and 26 years old, and the peak period is 14 to 16 years old. Electroencephalogram (EEG) ) usually manifests as bilateral spikes or multiple spikes and wavelike discharges in the center of the frontal lobe. Conventional imaging examinations usually have no pathological changes, but advanced imaging examinations (such as: MRI, PET) found that the medial prefrontal cortex, dorsolateral prefrontal cortex There are structural and functional abnormalities in the cortex and thalamus, accompanied by dysfunction of the thalamofrontal cortex network. Neuropsychological studies have found that patients have cognitive deficits

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