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Pharmaceutical composition for resisting swine stress diseases

A composition and anti-stress technology, applied in the field of livestock and poultry drugs, can solve the problems of slow speed, slow absorption, and low oral bioavailability

Inactive Publication Date: 2021-07-16
成都彤琦恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] While the combination of valerian and hops is effective as a sleep aid, it does not work as quickly because they are absorbed into the bloodstream more slowly
The purpose of the present invention is to overcome the slow absorption of valerian root and hops as an oral preparation, or the defects of low oral bioavailability, and provide a plant or component that can promote the rapid absorption of the functional components of valerian root and hops into the blood, The combination of the three improves the oral bioavailability of the pharmaceutical composition

Method used

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  • Pharmaceutical composition for resisting swine stress diseases

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Divide the medicinal materials to be decocted into 4 groups, and the combined amount of spider incense and hops in each group is a fixed amount, which contains 60g spider incense and 13g hops; except that the control group has no black pepper added, each group adds black pepper respectively Or black pepper granules 0.05g, 0.1g and 0.5g (hereinafter referred to as the present invention 1, 2, 3), add water to the medicine jar, decoct 3 times after soaking for 1 hour, each 30 minutes. The decoctions were combined and concentrated 10 times for later use.

Embodiment 2

[0016] The Caco-2 cell model is a well-recognized human small intestinal epithelial cell model in vitro. The permeability of drugs in Caco-2 cells has a good correlation with the absorption of drugs in the upper layer of human small intestinal mucosa. Absorption and transport in human intestinal cells, etc. In order to study the effect of different doses of pepper on improving the absorption and bioavailability of the present invention, Caco-2 cells were treated with 2×10 5 / mL cells were inoculated into a transwell-6-well plate and cultured for 21 days. During the cultivation period, the resistance value was detected with a transmembrane resistance meter, when the resistance value of the experimental hole was about 700Ω.cm 2 2.6 mL of the culture system of the present invention was added to the upper chamber, and 2 mL of HBSS solution was added to the lower chamber. -1 ). Samples were taken from the lower layer at 10, 30, and 60 minutes, respectively.

[0017] After the s...

Embodiment 3

[0021] Embodiment 3 The present invention is to the influence of mouse pentobarbital sodium hypnosis

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PUM

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Abstract

The invention relates to a pharmaceutical composition, which comprises at least one valerian extract, at least one hop extract and at least one pepper extract, is prepared by decocting or concentrating according to a proper proportion, and can resist various stress reactions, especially stress reactions of livestock and poultry caused by various stimulation factors.

Description

technical field [0001] The invention relates to the technical field of medicines for livestock and poultry, in particular to a preparation method and application of a pharmaceutical composition for livestock and poultry. [0002] Background of the invention [0003] The stress response of livestock and poultry refers to the stress response of extreme excitement and mania caused by various strong stimuli (such as capture, drive, shipment, fright, etc.) during transportation, which often occurs in pigs, chickens and pigs. During the transportation of ducks and other livestock and poultry, it can lead to the death of livestock and poultry in serious cases, and bring great losses to the livestock and poultry breeding industry. The current anti-stress measures are to give drugs such as intramuscular injection of sedative drugs such as chlorpromazine to keep the stressed pigs in a normal state. Sedative drugs. [0004] Valerian is a plant of the genus Valeriana in the family Patr...

Claims

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Application Information

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IPC IPC(8): A61K36/84A61P39/00
CPCA61K36/60A61K36/67A61K36/84A61K2236/331A61K2236/39A61P39/00A61K2300/00
Inventor 代燕平
Owner 成都彤琦恩生物科技有限公司