Bacteriostatic nontoxic hydrogel dressing and preparation method thereof
A technology of hydrogel and antibacterial agent, applied in bandages, absorbent pads, medical science, etc., can solve the problems of toxicity and poor antibacterial effect
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Embodiment 1
[0036] A preparation method of a bacteriostatic and nontoxic hydrogel dressing, comprising a hydrogel matrix and bacteriostatic peptides. The hydrogel matrix is polyvinyl alcohol. Its preparation method is:
[0037] S1. Weigh 10 parts of polyvinyl alcohol (PVA) and pour it into a round bottom flask, add 100 parts of deionized water, stir at 100°C until the drug is completely dissolved, then stop heating; after it cools to room temperature, add 40 parts After the bubbles in the product disappear, pour the prepared gel into the mold, cover the glass sheet, fix it with clips, put it in the refrigerator for 12 hours, and obtain polyvinyl alcohol / antibacterial peptide after thawing Peptide hydrogel.
[0038] S2. After one side of the hydrogel is coated with polyacrylate pressure-sensitive adhesive, stick release paper and cut to obtain the antibacterial hydrogel dressing, as figure 1 and 2 shown.
Embodiment 2-5
[0040] The antibacterial and non-toxic hydrogel dressing in Example 2-5 is prepared in the same way as in Example 1, except that the addition of hydrogel matrix and bacteriostatic peptide is different, and the stirring temperature in step S1 is different. The details are shown in Table 1.
Embodiment 6
[0042] The difference between embodiment 6 and embodiment 1 is that in step S1 in embodiment 6, the solution after mixing polyvinyl alcohol and bacteriostatic peptide is spread on the surface of the expanded polytetrafluoroethylene film after graft modification, and then Freezing and thawing was carried out to obtain bacteriostatic peptide hydrogel.
[0043] The preparation method of described expanded polytetrafluoroethylene film is:
[0044] (1) choose the double-stretched expanded polytetrafluoroethylene film that the thickness of 0.1 micron is not coated with film of 150 microns, the film is cut into a square of 10cm x 10cm; the expanded polytetrafluoroethylene film is fixed on the flat glass, put Into the 20MHz vacuum plasma generation chamber; evacuate and feed the argon gas at a flow rate of 20mL / min, adjust the equipment power to 115w, control the vacuum degree of the system to 0.095MPa, and conduct plasma treatment for 100s.
[0045] (2) Immediately transfer the film t...
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