Bacteriostatic nontoxic hydrogel dressing and preparation method thereof
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A technology of hydrogel and antibacterial agent, applied in bandages, absorbent pads, medical science, etc., can solve the problems of toxicity and poor antibacterial effect
Inactive Publication Date: 2021-07-30
SICHUAN UNIVERSITY OF SCIENCE AND ENGINEERING +1
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Problems solved by technology
[0005] Aiming at the above-mentioned deficiencies in the prior art, the purpose of the present invention is to solve the problem of poor antibacterial effect and toxicity of existing hydrogel materials, and provide a kind of antibacterial and non-toxic hydrogel dressing
Method used
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Embodiment 1
[0036] A preparation method of a bacteriostatic and nontoxic hydrogel dressing, comprising a hydrogel matrix and bacteriostatic peptides. The hydrogel matrix is polyvinyl alcohol. Its preparation method is:
[0037] S1. Weigh 10 parts of polyvinyl alcohol (PVA) and pour it into a round bottom flask, add 100 parts of deionized water, stir at 100°C until the drug is completely dissolved, then stop heating; after it cools to room temperature, add 40 parts After the bubbles in the product disappear, pour the prepared gel into the mold, cover the glass sheet, fix it with clips, put it in the refrigerator for 12 hours, and obtain polyvinyl alcohol / antibacterial peptide after thawing Peptide hydrogel.
[0038] S2. After one side of the hydrogel is coated with polyacrylate pressure-sensitive adhesive, stick release paper and cut to obtain the antibacterial hydrogel dressing, as figure 1 and 2 shown.
Embodiment 2-5
[0040] The antibacterial and non-toxic hydrogel dressing in Example 2-5 is prepared in the same way as in Example 1, except that the addition of hydrogel matrix and bacteriostatic peptide is different, and the stirring temperature in step S1 is different. The details are shown in Table 1.
Embodiment 6
[0042] The difference between embodiment 6 and embodiment 1 is that in step S1 in embodiment 6, the solution after mixing polyvinyl alcohol and bacteriostatic peptide is spread on the surface of the expanded polytetrafluoroethylene film after graft modification, and then Freezing and thawing was carried out to obtain bacteriostatic peptide hydrogel.
[0043] The preparation method of described expanded polytetrafluoroethylene film is:
[0044] (1) choose the double-stretched expanded polytetrafluoroethylene film that the thickness of 0.1 micron is not coated with film of 150 microns, the film is cut into a square of 10cm x 10cm; the expanded polytetrafluoroethylene film is fixed on the flat glass, put Into the 20MHz vacuum plasma generation chamber; evacuate and feed the argon gas at a flow rate of 20mL / min, adjust the equipment power to 115w, control the vacuum degree of the system to 0.095MPa, and conduct plasma treatment for 100s.
[0045] (2) Immediately transfer the film t...
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Abstract
The invention discloses a bacteriostatic nontoxic hydrogel dressing and a preparation method thereof. The hydrogel dressing comprises a hydrogel matrix and a bacteriostatic agent, and the bacteriostatic and nontoxic hydrogel dressing is prepared from the hydrogel matrix and the bacteriostatic agent through physical crosslinking. The hydrogel matrix is polyvinyl alcohol or agarose, and the bacteriostatic agent is bacteriostatic peptide. The preparation method comprises the following steps: S1, weighing the hydrogel matrix, pouring into a container, adding deionized water, stirring until the medicine is completely dissolved, and stopping heating to obtain a hydrogel matrix solution; S2, after the hydrogel matrix solution obtained in the step S1 is cooled to room temperature, adding antibacterial peptide, and stirring; after bubbles in the product disappear, freezing for 10-12 hours, and unfreezing to obtain antibacterial peptide hydrogel; and S3, after one side of the hydrogel is coated with an outer layer film, pasting release paper, and shearing to obtain the bacteriostatic and nontoxic hydrogel dressing. The hydrogel dressing prepared by the invention has a relatively good antibacterial effect, is non-toxic and can effectively avoid wound infection.
Description
technical field [0001] The invention relates to the technical field of medical dressings, in particular to a bacteriostatic and non-toxic hydrogel dressing and a preparation method thereof. Background technique [0002] Traditional surgery uses gauze to cover the wound, but the gauze needs to be changed every few hours until the wound scabs over. The yarn is easy to adhere to the wound, and it is easy to cause secondary damage to the wound when it is replaced, forming a chronic wound, delaying healing, and even threatening life. For this reason, modern medicine has developed hydrogel dressings. The inner layer of the hydrogel dressing is often the hydrogel that can directly cover the wound, which can promote wound healing and the outer layer is non-woven fabric or polyurethane cloth, which has good air permeability. At the same time, the dosage form of the hydrogel can improve the treatment efficiency of the drug on the lesion, and provide a better strategy for the clinica...
Claims
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