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A kind of microemulsion gel of anti-HPV plant extract and preparation method and application thereof

A technology of plant extract and microemulsion gel, which is applied in microemulsion gel of anti-HPV plant extract and its preparation, anti-HPV application field, can solve problems such as poor adhesion, achieve low cost, high safety, The effect of enhancing the efficacy of anti-HPV

Active Publication Date: 2022-07-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, the nanoscale structure (10-100nm) formed spontaneously by microemulsions is conducive to enhancing cell uptake, but there are problems such as poor adhesion when applied alone on skin and mucosal surfaces

Method used

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  • A kind of microemulsion gel of anti-HPV plant extract and preparation method and application thereof
  • A kind of microemulsion gel of anti-HPV plant extract and preparation method and application thereof
  • A kind of microemulsion gel of anti-HPV plant extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A microemulsion gel of anti-HPV plant extract, the steps are as follows:

[0049] (1) Weigh carbomer 934 powder (1g) and swell in 50g purified water for 12h;

[0050] (2) in step (1), add borneol (0.5g), stir well, adjust pH to 6.5 with triethanolamine to obtain gel;

[0051] (3) Weigh Curcuma curcuma extract (1.5g), Eucalyptus extract (1.5g), Sophora flavescens extract (1.5g) respectively, add Tween 80 (10g) after mixing, and heat at 25°C and 40rpm. Add purified water dropwise until the system becomes clear from turbidity to obtain microemulsion;

[0052] (4) Mix the gel in step (1) with the microemulsion obtained in step (3) at a mass ratio of 1:3, and stir evenly to obtain.

[0053] The sensory index and stability of the plant extract microemulsion gel prepared in this example are shown in Table 1.

[0054] Table 1 Comprehensive evaluation of sensory indexes and experimental indexes of plant extract microemulsion gel

[0055]

[0056] It can be seen from Table...

Embodiment 2

[0058] A microemulsion gel of anti-HPV plant extract, the steps are as follows:

[0059] (1) Weigh carbomer 940 powder (1 g) and swell it in 50 g of purified water for 12 h;

[0060] (2) in step (1), add borneol (1g), stir, and triethanolamine adjusts pH to 5.5 to obtain gel;

[0061] (3) Weigh eucalyptus leaf extract (8g), add Tween 80 (8g), Tween 20 (2g), mix well, add purified water dropwise at 25°C, 60rpm until the system becomes clear from turbidity obtain microemulsion;

[0062] (4) Mix the gel of step (1) and the microemulsion of step (3) in a mass ratio of 1:3, and stir to obtain.

Embodiment 3

[0064] A microemulsion gel of anti-HPV plant extract, the steps are as follows:

[0065] (1) Weigh carbomer 941 powder (1.5g) and swell in 50g purified water for 12h;

[0066] (2) in step (1), add borneol (1g), stir, and adjust pH to 6.5 with triethanolamine to obtain gel;

[0067] (3) Weigh Curcuma curcuma extract (1.5g) and Baibu extract (1.5g), add Span 80 (6g), mix well, add purified water dropwise at 25°C and 60rpm until the system changes from turbidity to turbidity. Microemulsion is obtained for clarification;

[0068] (4) Mix the gel of step (1) and the microemulsion of step (3) at a mass ratio of 1:2, and stir to obtain.

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Abstract

The invention discloses an anti-HPV plant extract microemulsion gel and a preparation method and application thereof. The microemulsion gel includes plant extracts and auxiliary materials, and the plant extracts include one or more of the following: Curcuma curcuma extract , Eucalyptus leaf extract, Sophora flavescens extract, Cnidium extract, Bai Bu extract, Phellodendron chinensis extract. In the present invention, natural plant extracts can be used as a component of a carrier, and at the same time, as an active ingredient to enhance the improvement of drug efficacy, and carbomer is used as a matrix to prepare a topical preparation with antibacterial, anti-inflammatory and antiviral properties, which is used for Microemulsion gel for HPV infection and prevention, bacterial and fungal vaginitis, cervical erosion, and daily care of women's private parts can especially reduce the mRNA expression levels of key oncogenes E6 and E7 in Hela cells. The microemulsion gel prepared by the invention has high safety, good stability, convenient administration and strong patient compliance; the processing technology is simple, the cost is low, and the mass production is convenient.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to an anti-HPV plant extract microemulsion gel, a preparation method thereof and an anti-HPV application. Background technique [0002] HPV, that is, human papillomavirus, has obvious tropism for human skin and mucosal epithelial cells. The pathogenesis of HPV is mainly related to immune escape: the virus integrates into particle molecules in epithelial cells, so that the entire life cycle of the virus cannot be absorbed by cells. In the state of dissolution of endolytic enzymes, the immune response of the body is reduced; after the HPV virus infects the body, it will also integrate its own genes into the host genes, further evading immune system monitoring. HPV subtypes are divided into several minutes, among which the mucosal high-risk type is mainly HPV16 / 18, and the expression of related proteins is mainly regulated by E6 and E7 genes. Persistent infection of high-risk HPV is t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/9066A61K47/32A61K47/10A61P15/02A61P31/20A61P31/04A61P31/10
CPCA61K36/9066A61K36/61A61K36/489A61K36/234A61K36/904A61K36/756A61K9/06A61K9/0034A61K47/32A61K47/10A61P15/02A61P31/20A61P31/04A61P31/10A61K2300/00
Inventor 李斯文李钰
Owner CHINA PHARM UNIV
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