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ApoA-based chronic lymphocytic leukemia prognosis risk assessment system and application thereof

A risk assessment system and lymphocyte technology, applied in the field of chronic lymphocytic leukemia prognostic risk assessment system, can solve problems such as incurable CLL

Active Publication Date: 2021-08-13
SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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Problems solved by technology

Despite improved survival in CLL patients with new targeted inhibitors, such as the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib and the B-cell lymphoma 2 (Bcl2) inhibitor venetoclax, high-risk CLL remains incurable of

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  • ApoA-based chronic lymphocytic leukemia prognosis risk assessment system and application thereof
  • ApoA-based chronic lymphocytic leukemia prognosis risk assessment system and application thereof
  • ApoA-based chronic lymphocytic leukemia prognosis risk assessment system and application thereof

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Embodiment

[0058] 1. Materials and Methods

[0059] 1.1 Patient

[0060] Our study included 150 patients with CLL newly diagnosed at Shandong Provincial Hospital Affiliated to Shandong University from January 2010 to December 2019. All patients met the revised diagnostic criteria of the International Workshop on Chronic Lymphocytic Leukemia (IWCLL). The definitions of overall survival (OS) and progression-free survival (PFS) were also based on this. The last follow-up was in April 2020. This study was approved by the Hospital Ethics Committee of Provincial Hospital Affiliated to Shandong University. All participants signed the informed consent. All data are carried out following the Declaration of Helsinki.

[0061] 1.2 Cell lines and reagents

[0062] The human p53 deletion / mutant CLL cell line MEC1 cells and the human p53-broad CLL cell line EHEB cells were obtained from Moores Cancer Center, University of California, San Diego, and the American Type Culture Collection (ATCC), re...

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Abstract

The invention provides an ApoA-based chronic lymphocytic leukemia prognosis risk assessment system and application thereof, and belongs to the technical field of biological medicine and molecular biology. The prognosis value of ApoA in chronic lymphocytic leukemia is proved, and the inhibition effect of L-4F on a CLL cell line and primary cells is proved in a cell experiment, which can provide a new direction for the treatment of CLL. On the other hand, a new ApoA and ADA-based risk rating system-ARAA risk rating system is established, and the effect of the ARAA risk rating system in evaluating the OS and PFS of the CLL patient is proved. The ARAA risk degree scoring system is superior to Binet grading, and plays a role in optimizing CLL patient risk degree layering, so that the ARAA risk degree scoring system has good practical application value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and molecular biology, and specifically relates to an ApoA-based chronic lymphocytic leukemia prognosis risk assessment system and its application. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Chronic lymphocytic leukemia (CLL) is a heterogeneous disease characterized by the coexpression of CD5 and CD23 by small but mature malignant B lymphocytes. Despite improved survival in CLL patients with new targeted inhibitors, such as the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib and the B-cell lymphoma 2 (Bcl2) inhibitor venetoclax, high-risk CLL remains incurable of. Over the past 40...

Claims

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Application Information

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IPC IPC(8): G01N33/574G01N33/68G01N33/573G16H50/30G16H50/70G16B40/00
CPCG01N33/57426G01N33/57488G01N33/68G01N33/573G16H50/30G16H50/70G16B40/00G01N2333/775G01N2333/978
Inventor 张娅王欣云晓雅
Owner SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY
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