Biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and detection method and application of biomarker

A biomarker and diabetes technology, applied in the field of biomedicine, can solve the problems of no research exploration relationship, no research to explore the value of SphK sphingolipid metabolites on the prediction of diabetes, etc., to achieve the effect of improving accuracy and high correlation
CN113295793AActive Publication Date: 2021-08-24ZHONGSHAN HOSPITAL FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
ZHONGSHAN HOSPITAL FUDAN UNIV
Publication Date
2021-08-24

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Abstract

The invention discloses a biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and a detection method and application of the biomarker, and belongs to the technical field of biological medicines. The biomarkers are sphingosine dihydrogen (dhSph) and sphingosine 1-phosphate (dhS1P) in serum, the levels of the dhS1P and the dhSph in a serum sample of a subject are detected through high performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS), and the ratio of the dhS1P to the dhSph is calculated; wherein the level of the ratio of dhS1P to dhS1P / dhSph in the serum sample is in positive correlation with the increase of the risk of diabetes; traditional diabetes risk factors including age, body mass index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting blood glucose, postprandial blood glucose, insulin resistance index and systolic pressure are combined to predict early diabetes, and the biomarker has high prediction value.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and specifically relates to a biomarker for predicting early diabetes and diabetes occurrence, a detection method and application thereof. Background technique

[0002] Type 2 diabetes (T2DM) is a major global health problem, currently affecting 463 million people worldwide. Diabetes is estimated to account for approximately 4.2 million deaths among adults aged 20-79, accounting for 11.3% of total global deaths in 2019. The most effective way to reduce this global health burden is to prevent diabetes itself, because Prevention of diabetes may reduce all-cause mortality and cardiovascular disease mortality by 38.8% and 44.2%, respectively. However, the current main prevention strategies are still not enough to curb the rising prevalence of T2DM. Effective means and methods are urgently needed to screen high-risk groups and early diagnosis, and formulate targeted early prevention strategies an...

Claims

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