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Biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and detection method and application of biomarker

A biomarker and diabetes technology, applied in the field of biomedicine, can solve the problems of no research exploration relationship, no research to explore the value of SphK sphingolipid metabolites on the prediction of diabetes, etc., to achieve the effect of improving accuracy and high correlation

Active Publication Date: 2021-08-24
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

Although the above basic studies have shown that SphK plays an important role in the pathogenesis of insulin resistance and β-cell failure, there is still no research to explore the relationship between SphK and its related sphingolipid metabolites (Sph, S1P, dhSph, and dhS1P) in the population. There is no research on the predictive value of SphK and its related sphingolipid metabolites for diabetes

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  • Biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and detection method and application of biomarker
  • Biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and detection method and application of biomarker
  • Biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and detection method and application of biomarker

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[0016] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention more clear, the following will clearly and completely describe the technical solutions of the embodiments of the present invention in conjunction with the drawings of the embodiments of the present invention. Apparently, the described embodiments are some, not all, embodiments of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative effort fall within the protection scope of the present invention.

[0017] The subjects selected for the following clinical study are from the Shanghai "Changfeng Research" cohort, which is a prospective cohort study based on community population. Among the 2486 non-diabetic subjects at baseline, 100 new subjects were randomly selected after 5 years of follow-up. Each case of patients with T2DM was matched with individ...

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Abstract

The invention discloses a biomarker for predicting early diabetes mellitus and diabetes mellitus occurrence and a detection method and application of the biomarker, and belongs to the technical field of biological medicines. The biomarkers are sphingosine dihydrogen (dhSph) and sphingosine 1-phosphate (dhS1P) in serum, the levels of the dhS1P and the dhSph in a serum sample of a subject are detected through high performance liquid chromatography-tandem mass spectrometry (HPLC-MS / MS), and the ratio of the dhS1P to the dhSph is calculated; wherein the level of the ratio of dhS1P to dhS1P / dhSph in the serum sample is in positive correlation with the increase of the risk of diabetes; traditional diabetes risk factors including age, body mass index, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting blood glucose, postprandial blood glucose, insulin resistance index and systolic pressure are combined to predict early diabetes, and the biomarker has high prediction value.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to a biomarker for predicting early diabetes and diabetes occurrence, a detection method and application thereof. Background technique [0002] Type 2 diabetes (T2DM) is a major global health problem, currently affecting 463 million people worldwide. Diabetes is estimated to account for approximately 4.2 million deaths among adults aged 20-79, accounting for 11.3% of total global deaths in 2019. The most effective way to reduce this global health burden is to prevent diabetes itself, because Prevention of diabetes may reduce all-cause mortality and cardiovascular disease mortality by 38.8% and 44.2%, respectively. However, the current main prevention strategies are still not enough to curb the rising prevalence of T2DM. Effective means and methods are urgently needed to screen high-risk groups and early diagnosis, and formulate targeted early prevention strategies an...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72G01N30/86
CPCG01N30/02G01N30/72G01N30/86
Inventor 陈琦夏朴高鑫王伟夏明锋林寰东李小英
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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