Application of chlorsulfuron benzene ring 5-substituted derivative in preparation of antitumor drugs

Abstract

The invention relates to an application of a chlorsulfuron benzene ring 5-substituted derivative in preparation of antitumor drugs. The general formula of the chemical structure of the chlorsulfuron benzene ring 5-substituted compound is shown in the specification, wherein R is selected from halogen, nitro, cyano, trifluoromethyl, halogenated C1-C6 alkyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, C1-C6 alkylthio, halogenated C1-C6 alkylthio, C1-C6 alkoxy carbonyl, halogenated C3-C6 cycloalkyl or N, N-(C1-C6 alkyl) carbamoyl, N, N-(C1-C6 alkyl) amino sulfonyl, N, O and S-containing ternary-five-membered heterocyclic ring is substituted by C1-C6 alkyl, N, O and S-containing ternary-five-membered heterocyclic ring and the N, O and S-containing ternary-five-membered heterocyclic ring substituted by C1-C6 alkyl. The invention discovers that the chlorsulfuron benzene ring 5-substituted derivative has an inhibition function on breast cancer cells for the first time, and can be used for preparing antitumor drugs.

Description

technical field [0001] The invention relates to the application of a class of derivatives substituted at the 5-position of chlorsulfuron benzene ring in the preparation of antitumor drugs Background technique [0002] Cancer, also known as malignant tumor, is an important disease that endangers human health. According to data released by the Ministry of Health in 2010, cancer has become an important factor in the death of Chinese people. Therefore, the treatment of cancer is particularly important. Cancer generally involves the mutation of multiple genes: when the genes that regulate cell growth are mutated or damaged, the programmed death of the cell itself is inhibited, making the cells grow out of control, continue to grow and divide, and then transform into tumors. At the same time, these tumors The process of cell infiltration and metastasis can accelerate the formation of tumor new capillaries. Although there are many antineoplastic drugs, there are few ideal drugs,...

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Problems solved by technology

There are very few domestic studies on sulfonylurea anti-tumor compounds, and there are few reports

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