Artificial intelligence-based basic culture medium formula development method and system

Abstract

The invention discloses an artificial intelligence-based basic culture medium formula development method and system. The method comprises the following steps: (1) establishing a sample formula database; (2) obtaining a sample formula culture database; (3) training a machine learning model by adopting the sample formula culture database obtained in the step (2) according to an optimization target to obtain a basic culture medium formula culture effect prediction model; and (4) performing culture effect regression prediction aiming at an optimization target by adopting the culture effect prediction model of the basic culture medium formula obtained in the step (3) in a search space of the adding proportion of each component in the basic culture medium formula to be optimized, and recommending the basic culture medium formula. The system comprises a sample formula generation module, a sample formula cultivation database, a regression model training module and a formula recommendation module. All components in the formula are analyzed at the same time, multiple DOE tests in a traditional method are avoided, therefore, the research and development speed is increased, and the basic culture medium formula development time is saved.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically relates to a method and system for developing basic culture medium formula based on artificial intelligence. Background technique [0002] Although the nutritional requirements of biological samples such as various microorganisms and cells are different, most biological samples require the same basic nutrients. The medium prepared according to the basic nutrients required for the growth and reproduction of general biological samples is called the basic medium. A serum-free, animal-source-free, chemically defined basal medium consisting of carbon sources, amino acids, vitamins, trace metal ions, lipids, buffering agents, and other additives. [0003] The traditional medium formula development method is based on one or several classical medium (such as DEME / F12), by adding a variety of different components, using single factor test or DOE screening test to find the key components...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the above defects or improvement needs of the prior art, the present invention provides a method and system for formula development of basic culture medium based on artificial intelligence. A sufficient number of sample formula databases, select the appropriate machine learning algorithm and optimization algorithm, recommend the basic medium formula that is most likely to have a good cultivation effect in a short period of time, reduce the threshold for formula development, and thus solve the existing basic medium components Complex technical issues resulting in slow development speed and high development costs

Images