Pharmaceutical composition with effect of improving intestines and stomach as well as preparation method and application of pharmaceutical composition

A technology of composition and efficacy, which is applied in the field of pharmaceutical composition with improved gastrointestinal efficacy and its preparation, which can solve the problems of difficulty in meeting the clinical needs of patients' gastrointestinal motility, limited applicable population and administration methods, and affecting patient compliance. , to achieve the effect of enhancing the ability to resist pathogenic bacteria and toxins, flexible application methods, promoting gastrointestinal peristalsis and the discharge of toxic substances

Active Publication Date: 2021-10-01
四川省食用菌研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the prior art, the utilization of Hericium erinaceus in improving the gastrointestinal tract often has the following defects: limited indications, many application contraindications, limited applicable population and application methods; insufficient dietary fiber content, difficult to meet the needs of enhancing gastrointestinal motility in patients Clinical needs, prone to repeated constipation symptoms; product clarity is not good, affecting the perception and taste, affecting the patient's compliance; Hericium erinaceus is fermented, resulting in Hericium erinaceus polysaccharides that have an inhibitory effect on Helicobacter pylori are consumed, reducing the efficacy of the product

Method used

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  • Pharmaceutical composition with effect of improving intestines and stomach as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition with effect of improving intestines and stomach as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition with effect of improving intestines and stomach as well as preparation method and application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The composition consists of:

[0057]

[0058] The preparation method of composition is:

[0059] (1) Mix the sterilized raw materials with probiotics (Bacillus coagulans, Bifidobacterium lactis, Rhamnosus) in proportion, add 10-15% of the total weight of water during the mixing process, stir well, and use 16 mesh Sieve granulation to obtain wet granules;

[0060] (2) Put the mixed sample in an oven and bake at 40°C for 40 minutes, and sieve it with a 20-mesh sieve to obtain dry granules;

[0061] (3) Add irradiated magnesium stearate, press into tablets, 1g per tablet, until the content of probiotics is ≤150 million per tablet.

Embodiment 2

[0063] The composition consists of:

[0064]

[0065] The preparation method of composition is:

[0066] (1) Sterilize the raw materials after mixing, and mix them in proportion with probiotics (Bacillus coagulans, Bifidobacterium lactis, Rhamnosus bacillus), add water accounting for 10-15% of the total weight during the mixing process, stir well, and use Granulate with a 16-mesh sieve to obtain wet granules;

[0067] (2) Put the mixed sample in an oven and bake at 40°C for 40 minutes, and sieve it with a 20-mesh sieve to obtain dry granules;

[0068] (3) Add irradiated magnesium stearate, press into tablets, 1g per tablet, probiotic content ≤ 150 million per tablet.

Embodiment 3

[0070] The composition consists of:

[0071]

[0072] The preparation method of composition is:

[0073] (1) Mix the raw materials and sterilize them, mix them with probiotics (Bifidobacterium lactis, Rhamnosacillus) in proportion, add water accounting for 10-15% of the total weight during the mixing process, stir well, and use a 16-mesh sieve to prepare Granules to obtain wet granules;

[0074] (2) Put the mixed sample in an oven and bake at 40°C for 40 minutes, and sieve it with a 20-mesh sieve to obtain dry granules;

[0075] (3) Add irradiated magnesium stearate, press into tablets, 1g per tablet, probiotic content ≤ 150 million per tablet.

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PUM

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Abstract

The invention relates to a pharmaceutical composition with an effect of improving the intestines and the stomach. The composition contains 20-60% of hericium erinaceus, 10-30% of hawthorn, 1-20% of monosaccharide, 1-10% of probiotics and a pharmaceutically acceptable carrier. The composition is suitable for preventing and treating gastrointestinal discomfort caused by various reasons, such as constipation, gastric ulcer, gastritis and the like, and has the advantages of not stimulating the intestines and the stomach, slowly improving intestinal functions, not causing rapid changes of blood sugar and blood pressure, being flexible in application mode, free of use taboos, capable of being used for a long time and the like.

Description

technical field [0001] The invention relates to the field of biology, and relates to a pharmaceutical composition capable of improving gastrointestinal function, a preparation method and application thereof. Background technique [0002] Hericium erinaceus is a fungus of the Dental family. As a food material, it is a delicious dish and also a medicinal material. Many studies in modern medicine and pharmacology have summarized the medicinal effects of Hericium erinaceus as improving immunity, anti-tumor, anti-aging, reducing Blood lipids, improvement of gastrointestinal and other physiological functions, among which the clinical application of gastrointestinal improvement includes constipation, indigestion, gastric ulcer, antral gastritis, stomach pain, bloating and other diseases. [0003] However, in the prior art, the utilization of Hericium erinaceus in improving the gastrointestinal tract often has the following defects: limited indications, many application contraindica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61K36/07A61K31/7004A61K36/064A61K35/742A61K35/747A61K35/745A61K35/741A61P1/00A61P1/10A61P1/14A61P1/04
CPCA61K36/07A61K36/734A61K31/7004A61K36/064A61K35/742A61K35/747A61K35/745A61K35/741A61P1/00A61P1/10A61P1/14A61P1/04A61K2300/00
Inventor 许瀛引唐杰张志远周洁何晓兰陈影彭卫红王勇
Owner 四川省食用菌研究所
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