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Application of microorganisms in preparation of product for diagnosing growth retardation

A growth and product technology, applied in the field of biomedicine

Pending Publication Date: 2021-10-22
BEIJING MEDINTELL BIOMED CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few related research reports on microbes and growth retardation. To study the relationship between microbes and growth retardation is expected to find suitable and convenient biomarkers for diagnosis or treatment of growth retardation.

Method used

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  • Application of microorganisms in preparation of product for diagnosing growth retardation
  • Application of microorganisms in preparation of product for diagnosing growth retardation
  • Application of microorganisms in preparation of product for diagnosing growth retardation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 Analysis of intestinal flora in children with extrauterine growth retardation

[0064] 1. Experimental method

[0065] 1. Research design

[0066] This study recruited extremely premature infants with a gestational age less than 32 weeks admitted to the Neonatal Intensive Care Unit of Beijing Friendship Hospital Affiliated to Capital Medical University from January to December 2018, and finally included 22 extremely premature infants. The physical development was evaluated 2 weeks after birth, and they were divided into extrauterine growth retardation group (EUGR group) and normal growth group (control group) according to body weight. At the same time, fecal samples were collected and stored at -80°C. High-throughput 16S rRNA sequencing was performed on the intestinal flora to analyze the relationship between extrauterine growth retardation and intestinal microecology in extremely premature sons. This study was approved by the Ethics Committee of Beijing Fri...

Embodiment 2

[0139] Example 2 Diagnostic efficacy analysis

[0140] According to the relative abundance of Chlamydiales bacterium CRIB 32, the receiver operating characteristic curve (ROC) was drawn using SPSS, and the binomial exact confidence space was calculated to analyze the sensitivity and specificity of Chlamydiales bacterium CRIB 32 for the diagnosis of extrauterine growth retardation.

[0141] result:

[0142] As shown in Table 1 and Table 2, the area under the ROC curve is 0.750, the cutoff value is 0.500, the specificity is 1.000, and the sensitivity is 0.500. These results prove that the application of Chlamydiales bacterium CRIB 32 in the diagnosis of extrauterine growth retardation has a high sensitivity, specificity and accuracy.

[0143] Table 1 Area under the curve

[0144]

[0145] Table 2 Chlamydiales bacterium CRIB 32 diagnostic efficacy data

[0146]

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Abstract

The invention relates to application of microorganisms in preparation of a product for diagnosing growth retardation. More specifically, the invention discloses a product capable of being used for predicting or diagnosing the growth retardation, and the product comprises a reagent for detecting the content or abundance of Chlamydiales_bacterium_CRIB_32 in a sample of a subject. A new method for predicting or diagnosing growth retardation is provided. The invention also discloses a pharmaceutical composition for preventing or treating the growth retardation, and the pharmaceutical composition comprises a substance capable of reducing the content or abundance of the Chlamydiales_bacterium_CRIB_32.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of microorganisms in the preparation of products for diagnosing growth retardation. Background technique [0002] With the establishment of intensive care units for premature infants and the extensive development of advanced life support technology for premature infants, the survival rate of premature infants has generally increased. However, many of the surviving premature infants have varying degrees of intrauterine and extrauterine growth retardation. Intrauterine growth retardation causes premature infants to have insufficient early nutritional reserves, lag in growth and development, and immature development of multiple organs, leading to the occurrence of various diseases, and some continue to suffer from extrauterine growth retardation. Similarly, premature infants with extrauterine growth retardation are caused by a variety of factors, which not only affect the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12Q1/6883C12Q1/6869A61K45/00A61P43/00
CPCC12Q1/689C12Q1/6883C12Q1/6869A61K45/00A61P43/00C12Q2600/158C12Q2600/136C12Q2531/113C12Q2535/122C12Q2563/107C12Q2537/165
Inventor 丁瑛雪姜丽娜崔红杨承刚
Owner BEIJING MEDINTELL BIOMED CO LTD