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Research method of action mechanism of Chinese angelica and six-yellow decoction for treating ulcerative colitis

A technology of ulcerative colitis and Danggui Liuhuang Decoction, applied in drug reference, instrument, biological system, etc.

Active Publication Date: 2021-11-02
SUN YAT SEN UNIV +1
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Problems solved by technology

Zhu Qing et al. reported that Danggui Liuhuang Decoction treated 48 cases of chronic non-specific ulcerative colitis, and found that those who took the traditional Chinese medicine Danggui Liuhuang Decoction had abdominal pain, diarrhea, tenesmus and other symptoms disappeared or improved faster, and those whose stool properties returned to normal were higher than those in the control group. The mental state has been significantly improved, and there is no report on the mechanism of Danggui Liuhuang Decoction in the treatment of ulcerative colitis.

Method used

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  • Research method of action mechanism of Chinese angelica and six-yellow decoction for treating ulcerative colitis
  • Research method of action mechanism of Chinese angelica and six-yellow decoction for treating ulcerative colitis
  • Research method of action mechanism of Chinese angelica and six-yellow decoction for treating ulcerative colitis

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Embodiment Construction

[0023] The present invention will be further described below by specific examples.

[0024] The flow chart of the main research steps in this embodiment is as follows: Figure 7 shown.

[0025] 1. Screening of active ingredients of Danggui Liuhuang Decoction and prediction of their targets

[0026] 1-1. Screening method and analysis platform

[0027] According to the traditional Chinese medicine system pharmacology platform (TCMSP) (https: / / tcmspw.com / tcmsp.php), "Angelica", "Rehmannia glutinosa", "Scutellaria baicalensis", "Huangqi", "Huangbai" and "Huanglian" All the chemical constituents of the six herbs were searched for keywords, and the chemical constituent database of Danggui Liuhuang Decoction (DGLHD) was established.

[0028] Oral bioavailability (OB) refers to the relative amount of a drug reaching the systemic circulation after oral administration. High oral bioavailability is an important indicator of whether the drug has biological activity; drug-likeness repre...

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Abstract

The invention relates to a research method of an action mechanism of Chinese angelica and six-yellow decoction for treating ulcerative colitis. The intersection target of the active component and the disease is obtained through database analysis of TCMSP, uniprot and the like. A protein-protein interaction (PPI) network is constructed based on String, and a result is visually analyzed by using Cytoscape software to obtain important modules and core targets in the PPI network. Gene GO and KEGG pathway enrichment analysis are performed on a target spot by adopting Metascape, to obtain a component-target spot-gene function-pathway-disease visual graph, and an action mechanism is analyzed. The method provides a new method for researching the drug-target interaction mechanism of the Chinese angelica and six-yellow decoction for treating ulcerative colitis; the problems that the number of interactions between multiple active ingredients and multi-target protein is too large and screening is difficult are solved, and the method has important application significance for guiding research and development of traditional Chinese medicine compounds.

Description

technical field [0001] The invention relates to the pharmacological research of Chinese medicinal compound, in particular to the research method of the mechanism of action of Danggui Liuhuang Decoction for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is an idiopathic chronic inflammatory disease of the colonic mucosa, and its incidence is on the rise worldwide. The global prevalence is expected to be as high as 30 million by 2025. The pathogenesis of U is multifactorial, involving genetic susceptibility, epithelial barrier defects, dysregulated immune responses, and environmental factors, among others. [0003] At present, there is still a lack of effective drugs and methods for the treatment of ulcerative colitis. Traditional corticosteroids and aminosalicylic acid anti-inflammatory drugs are still the main drugs used. In recent years, it has been discovered that the pathogenesis of chronic inflammatory diseases like ulcerative coliti...

Claims

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Application Information

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IPC IPC(8): G16H70/40G16H20/90G16B5/00
CPCG16H70/40G16H20/90G16B5/00Y02A90/10
Inventor 李静荣苏薇薇梁冰宜高永坚林碧珊曾杉陈锦霞
Owner SUN YAT SEN UNIV
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