Device for controlling temperature of chromatographic column and manufacturing method thereof

Abstract

The invention provides a device for controlling the temperature of a chromatographic column and a manufacturing method thereof. The device for controlling the temperature of the chromatographic column comprises the chromatographic column, a bottom plate, a cavity and a top plate. The device also comprises a heat conduction unit which is provided with heat dissipation teeth and is arranged on the inner side of the bottom plate; a refrigeration unit which is arranged on the outer side of the bottom plate and makes contact with the heat conduction unit; a circuit board arranged on the outer side of the cavity; a heating module which is wound on the chromatographic column, wherein the spiral chromatographic column is arranged on the upper side of the heat conduction unit and an electric wire connected with the heating module is connected with the circuit board; a temperature sensor arranged in the cavity, wherein an electric wire connected with the temperature sensor is connected with the circuit board; a heating seat which is provided with an opening and is arranged on the outer side of the cavity; a joint which is arranged in the heating seat and is communicated with the opening, wherein the two ends of the chromatographic column respectively penetrate through the through holes of the cavity and are connected with the joint; and a heater and a temperature measuring element which are respectively arranged in the heating seat. The device has the advantages of small size, low energy consumption and the like.

Description

technical field [0001] The invention relates to the field of chromatographic analysis, in particular to a device for controlling the temperature of a chromatographic column and a manufacturing method thereof. Background technique [0002] At present, the temperature control technology of the column thermostat mostly adopts the gas bath heating scheme, specifically, the heating wire gas bath heating realizes the programmed temperature rise of the chromatographic column, and the power required for heating is relatively high (about 2000W), and the temperature control range is usually room temperature +10 ℃~400℃, and some low boiling point substances need to be separated effectively at a lower temperature, and ordinary column ovens cannot achieve effective separation of low boiling point substances. [0003] In order to solve the problem of high power of the column thermostat, some companies have introduced miniaturized column thermostats, but the gas bath heating method is stil...

AI Technical Summary

Problems solved by technology

[0002] At present, the temperature control technology of the column thermostat mostly adopts the gas bath heating scheme, specifically, the heating wire gas bath heating realizes the programmed temperature rise of the chromatographic column, and the power required for heating is relatively high (about 2000W), and the temperature control range is usually room temperature +10 ℃~400℃, and some low boiling point substances need to be separated effectively at a lower temperature, and ordinary column ovens cannot achieve effective separation of low boiling point substances

[0003] In order to solve the problem of high power of the column thermostat, some companies have introduced miniaturized column thermostats, but the gas bath heating method is still used for chromatographic column heating. The disadvantage of this method is that it cannot solve the heat loss caused by gas bath heating. question;

[0004] Aiming at the problem of low-temperature separation, the prior art uses liquid nitrogen or liquid CO to the column box 2 The method provides a lower initial temperature for the column oven. The disadvantage of this method is that it cannot achieve precise control of the low temperature.

Images