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A near-infrared fluorescent probe for detecting zinc ions and its preparation method and application

A fluorescent probe, zinc ion technology, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve problems such as metal pollution, achieve the effect of enhanced fluorescence intensity and specific recognition response

Active Publication Date: 2022-05-06
XUCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the problem of metal pollution is becoming more and more serious. Due to the complexity of the biological chain, the problem of biological diseases caused by abnormal metal ion content is also increasing.

Method used

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  • A near-infrared fluorescent probe for detecting zinc ions and its preparation method and application
  • A near-infrared fluorescent probe for detecting zinc ions and its preparation method and application
  • A near-infrared fluorescent probe for detecting zinc ions and its preparation method and application

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Experimental program
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Embodiment 1

[0037] The preparation method of the fluorescent probe of the present embodiment comprises the following steps:

[0038]

[0039] (1) Preparation of Compound LF-2

[0040] Take 8 mL of concentrated sulfuric acid (commercially available 98% concentrated sulfuric acid) in a 50 mL pear-shaped bottle, and stir at 0 °C for 20 min. Cyclohexanone (0.2941 g, 3.0 mmol) was slowly injected into the bottle, stirred for 15-20 min, and then LF-1 (0.4691 g, 1.5 mmol) was added to the reaction solution in small amounts and controlled within 30 min After the addition, the solution gradually changed from colorless to red. After the solid was completely dissolved, it was heated at 92 °C for 4 h. After the reaction was complete, the heating was stopped and cooled to room temperature. water beaker, and stirred, then added dropwise 1.5 mL HClO 4 (Generally 10-16 times the molar weight of LF-1), accompanied by the precipitation of a red solid, filtered with suction, washed with cold water, and...

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Abstract

The invention discloses a near-infrared fluorescent probe for detecting zinc ions and its preparation method and application, and belongs to the technical field of organic synthesis. The fluorescent probe uses rhodamine hemicyanine as a fluorophore, and 7-hydroxy-4- Methyl coumarin aldehyde is used as the recognition group, which realizes the specific recognition response to zinc ions. The specific structural formula is as follows:; the fluorescence of the probe itself is extremely weak, and the fluorescence increases after reacting with zinc ions, and the solution changes from colorless to green. It can be identified with naked eyes and is not affected by interfering ions. It can be used for the detection of zinc ions, and it also has broad application scenarios in the biological field.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a near-infrared fluorescent probe for detecting zinc ions, a preparation method and application thereof. Background technique [0002] While our living standards are improving day by day, people are paying more and more attention to their own health problems. Metal ions not only widely participate in various physiological activities in organisms but also maintain various balances in the body. However, the problem of metal pollution is becoming more and more serious. Due to the complexity of the biological chain, the problem of biological diseases caused by abnormal metal ion content is also increasing. Therefore, it is particularly important to detect the ion content in living organisms and to understand the pathogenesis of diseases for doctors, one is to prevent the occurrence of diseases in advance, and the other is to provide convenience for follow-up tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/052C09K11/06G01N21/64
CPCC07D491/052C09K11/06G01N21/643G01N21/6428G01N21/6447G01N21/6486C09K2211/1029C09K2211/1033C09K2211/1088
Inventor 许志红周起航杨莉刘高兵杨涵熙许泗林许锐杰高志颖段颖颖潘明霞
Owner XUCHANG UNIV
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