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A kind of near-infrared fluorescent probe for detecting chromium ion and aluminum ion and its preparation method and application

A technology of fluorescent probes and aluminum ions, applied in chemical instruments and methods, fluorescence/phosphorescence, luminescent materials, etc., can solve the problems of fewer fluorescent sensors, limit the development of probes, interfere with cell fluorescence imaging, etc., and achieve enhanced fluorescence intensity Effect

Active Publication Date: 2022-05-17
XUCHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cr 3+ The increase or decrease of the content will affect the normal physiological activities and increase the risk of disease
Due to Cr 3+ Due to its own paramagnetic properties, it is easy to quench the fluorescence, because the fluorescence quenching is not easy to identify the output of the fluorescent signal, which interferes with the fluorescence imaging of the cells, thus limiting the detection of Cr 3+ The development of the probe
In particular, the development of Cr that can be used in organisms at the cellular level 3+ The near-infrared fluorescence sensor is a fluorescence-enhanced type, which is very difficult and challenging
[0005] Currently targeting Al 3+ or Cr 3+ Fluorescence sensors that excite and emit in the near-infrared region rarely

Method used

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  • A kind of near-infrared fluorescent probe for detecting chromium ion and aluminum ion and its preparation method and application
  • A kind of near-infrared fluorescent probe for detecting chromium ion and aluminum ion and its preparation method and application
  • A kind of near-infrared fluorescent probe for detecting chromium ion and aluminum ion and its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0037] The preparation method of the fluorescent probe of the present embodiment comprises the following steps:

[0038]

[0039] (1) Preparation of Compound LF-2

[0040] Take 8 mL of concentrated sulfuric acid (commercially available 98% concentrated sulfuric acid) in a 50 mL pear-shaped bottle, and stir at 0 °C for 20 min. Cyclohexanone (0.2941 g, 3.0 mmol) was slowly injected into the bottle, stirred for 15-20 min, and then LF-1 (0.4691 g, 1.5 mmol) was added to the reaction solution in small amounts and controlled within 30 min After the addition, the solution gradually changed from colorless to red. After the solid was completely dissolved, it was heated at 92 °C for 4 h. After the reaction was complete, stop heating, cool to room temperature, and then slowly pour the reaction solution into 480 mL of ice water. beaker, and stirred, then added dropwise 1.5 mL HClO 4 , accompanied by the precipitation of a red solid, which was filtered with suction, washed with cold w...

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Abstract

The invention belongs to the technical field of organic synthesis, and specifically relates to a near-infrared fluorescent probe for detecting chromium ions and aluminum ions and its preparation method and application. The fluorescent probe of the invention uses rhodamine hemicyanine as a fluorophore, 8-hydroxyquinoline-2-formaldehyde is the recognition group, which realizes the specific recognition response to chromium ions and aluminum ions. The structure of the probe is as follows:; Enhanced, the solution changes from colorless to green, which can be identified with the naked eye, and is not affected by interfering ions, and can be used for the detection of chromium ions and aluminum ions. It has broad application scenarios in the biological field.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and specifically relates to a near-infrared fluorescent probe for detecting chromium ions and aluminum ions, a preparation method and application thereof. Background technique [0002] Metal ions are widely used in our daily life, such as in our heavy industry, light industry, textile industry, food processing, and pharmaceutical production process, which brings great convenience to our life and production. We live in an environment accompanied by metal ions for a long time. Different metal ions through the food chain accumulate in the human body, and enrichment may cause a series of diseases caused by metal ions, such as slow growth, memory impairment, cancer and other diseases. Therefore, health problems caused by metal ions are also attracting more and more attention. [0003] Al 3+ It is especially common in our living environment, such as our kitchen utensils, food additives, fo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/107C09K11/06G01N21/64
CPCC07D491/107C09K11/06G01N21/6428G01N21/643C09K2211/1033C09K2211/1029
Inventor 许志红周起航杨莉刘高兵杨涵熙许泗林许锐杰高志颖段颖颖潘明霞
Owner XUCHANG UNIV
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