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Application of biomarker in preparation of reagent for predicting prognosis of colorectal cancer patient

A biomarker, colorectal cancer technology, applied in the application field of reagents, can solve the problem of lack of markers for the prognosis of colorectal cancer patients

Pending Publication Date: 2021-11-30
SHENZHEN HAPLOX BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, there is currently a lack of prognostic markers for colorectal cancer patients

Method used

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  • Application of biomarker in preparation of reagent for predicting prognosis of colorectal cancer patient
  • Application of biomarker in preparation of reagent for predicting prognosis of colorectal cancer patient
  • Application of biomarker in preparation of reagent for predicting prognosis of colorectal cancer patient

Examples

Experimental program
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Effect test

Embodiment

[0056] In this example, clinical trials were conducted to study the relationship between the mutation status of KRAS gene, NRAS gene, HRAS gene and BRAF gene in circulating tumor DNA and the prognosis of metastatic colorectal cancer patients receiving first-line treatment.

[0057] clinical trial design

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Abstract

The invention discloses application of a biomarker in preparation of a reagent for predicting prognosis of a colorectal cancer patient. The biomarker related to the reagent comprises a KRAS gene, an NRAS gene, an HRAS gene and a BRAF gene, can be used for detecting the mutation state of the biomarker in circulating tumor DNA in peripheral blood, and is applied to predicting prognosis of a metastatic colorectal cancer patient receiving first-line treatment. According to the invention, the application of the biomarker in preparation of the reagent for predicting prognosis of the colorectal cancer patient can be provided.

Description

technical field [0001] The present invention generally relates to the technical field of gene detection services, and specifically relates to the application of a biomarker in the preparation of reagents for predicting the prognosis of colorectal cancer patients. Background technique [0002] Colorectal cancer is the third most common cancer worldwide and is still increasing in many countries. Colorectal cancer is also the second leading cause of cancer-related death, with a five-year mortality rate of approximately 40%. With the development of molecular diagnostic techniques, the diagnosis and treatment options for patients with metastatic colorectal cancer have been greatly improved, and there are currently many types of treatment strategies, including chemotherapy, targeted and immunotherapy. In terms of medication guidance and prognosis prediction, the detection of somatic mutations in tumor patients plays a vital role in the course management of colorectal cancer patie...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/156
Inventor 徐瑞华许明炎王峰陈实富
Owner SHENZHEN HAPLOX BIOTECH
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