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Preparation method of high-purity Rosavin

A high-purity technology of rosavis, which is applied in the field of preparation of high-purity rosavis, can solve the problems of uneven product quality and achieve the effect of high purity

Pending Publication Date: 2021-12-07
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, there is currently a lack of standardized and unified standard samples of rosavis in the domestic market, and the quality of products varies. Therefore, a method that can separate high-purity rosavis is urgently needed to provide high-purity rosavis as a standard sample of rosavis. Further standardize the quality of Rhodiola rosea extract and related products to ensure the quality of functional food, health food and cosmetics made from this material

Method used

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  • Preparation method of high-purity Rosavin
  • Preparation method of high-purity Rosavin
  • Preparation method of high-purity Rosavin

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Embodiment 1

[0045] Embodiment 1: A kind of preparation method of high-purity rosavi

[0046] Include the following steps:

[0047] (1) take the dried rhizome of Rhodiola rosea (RhodioLa rosea L.) as raw material, cross 50 mesh sieves to obtain Rhodiola rosea powder after pulverizing, add 60% ethanol solution of 5 times of weight in Rhodiola rosea powder, Heating to 58°C for reflux extraction for 3.5h to obtain the extract (0.6% yield); then use 6 times the weight of petroleum ether to extract the extract at room temperature for 3 times, and 8 times the weight of ethyl acetate for 3 times at room temperature; at a temperature of 45°C Concentrate for 2.5 hours under the conditions of about 0.15 pma and vacuum, and concentrate to an alcohol-free state to obtain the crude extract of rosavi.

[0048] (2) Adsorb the crude extract of Luosaiwei on the HPD400A macroporous adsorption resin column. The mass ratio of the crude extract of Luosaiwei to the macroporous adsorption resin is 1:50 for adso...

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Abstract

The invention discloses a preparation method of high-purity Rosavin. The preparation method comprises the following steps of: carrying out reflux extraction on the roots and the stems of herba rhodiolae by using an ethanol solution, respectively extracting by using petroleum ether and ethyl acetate, and concentrating extract liquor to obtain a Rosavin crude extract; carrying out separation and enrichment on the Rosavin crude extract by using macroporous adsorption resin, and eluting by using ethanol to obtain a Rosavin eluate; separating the Rosavin eluate by using a high-speed counter-current chromatography separation technology to obtain a Rosavin crude product; purifying the Rosavin crude product by using preparative high performance liquid chromatography to obtain a Rosavin refined product; and drying the Rosavin refined product in vacuum to obtain the high-purity Rosavin. The purity of the separated and extracted Rosavin is high, the purity is larger than 98.5%, and the obtained Rosavin can be used as a standard sample of the Rosavin.

Description

technical field [0001] The invention relates to a preparation method of high-purity rosavi, which belongs to the technical field of extracting medicinal components. Background technique [0002] Rhodiola has obvious anti-oxidation, anti-tumor, anti-virus, anti-fatigue, anti-radiation, lowering blood pressure, lowering blood fat and other effects. Due to the various pharmacological activities of Rhodiola rosea, the research on the medicinal and health care functions of Rhodiola rosea extract has become popular at present, and health food and cosmetics with Rhodiola rosea extract as the main raw material have been launched one after another. Rosavin is one of the main active ingredients in Rhodiola rosea, and it is also one of the main indicators for evaluating the quality of Rhodiola rosea extract in the market. [0003] Rosavin, CAS: 84954-92-7, molecular formula: C 20 h 28 o 10 , Molecular weight: 428.43, Chemical name: β-D-Glucopyranoside, (2E)-3-phenyl-2-propen-1-yl 6...

Claims

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Application Information

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IPC IPC(8): C07H15/18C07H1/08
CPCC07H15/18C07H1/08C07B2200/07
Inventor 裴栋邸多隆
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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