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Methods of diagnosing and typing adult Still's disease

An adult, fractional technique for diagnosing and classifying adults with Still's disease

Pending Publication Date: 2021-12-10
陈得源
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no research data on circulating lncRNA expression in AOSD patients

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  • Methods of diagnosing and typing adult Still's disease
  • Methods of diagnosing and typing adult Still's disease
  • Methods of diagnosing and typing adult Still's disease

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Embodiment

[0048] Through the following specific examples, the scope of practical application of the present invention can be further proved. These are only preferred embodiments of the present invention, and do not limit the scope of the present invention. Therefore, any simple changes and modifications made according to the scope of the present invention and the content of the description of the present invention are still covered by the scope of the present invention.

[0049] method

[0050] Subjects: 41 consecutive AOSD patients meeting Yamaguchi criteria. Patients with infection, malignancy or other rheumatic diseases were excluded (Table 1).

[0051]

[0052] Table 1. Diagnostic criteria for adult Still's disease.

[0053] Systemic activity was assessed in each AOSD patient using the modified Pouchot score, where active AOSD was defined as an activity score of 4 or higher. This general activity score (range 0-12) assigns a point for each of the following 12 manifestations: ...

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Abstract

The present invention relates to a method of diagnosing and further determining the course of the disease in an individual with adult Still's disease. The method includes the following steps: (a) providing a blood sample and peripheral blood mononuclear cells; (b) detecting the expression level of the protein biomarker IL-18 in the blood sample; (c) detecting the expression of long-chain non-coding RNA biomarkers MIAT or THRIL in the peripheral blood mononuclear cells; (d) calculating the A-score by using the predicted function obtained by multiple regression analysis with the expression levels of IL-18, MIAT and THRIL detected in steps (b) and (c); (d) calculating the A-score by using the predicted function obtained by multiple regression analysis with the expression levels of IL-18, MIAT and THRIL detected in steps (b) and (c); and (e) comparing the A-score calculated in step (d) with a critical value, obtained by the receiver operating characteristic curve method, corresponding to the area under the ROC curve reaching a maximum, the A-score above the critical value value indicates that the individual suffers from adult Still's disease. The sequence of step (b) and step (c) can be reversed, which does not affect the judgment of the embodiment of the present invention and the final result.

Description

technical field [0001] The present invention relates to a method for diagnosing and typing adult Still's disease patients. Background technique [0002] Adult-Onset Still's Disease (AOSD) is an idiopathic inflammatory disorder characterized by fever, rash, arthralgia or arthritis, multisystem involvement, and elevated levels of acute-phase reactants. Diagnosis is usually delayed due to persistent high fever. Most patients are diagnosed only after secondary symptoms develop and more common conditions such as infection or other malignancies have been ruled out. Despite these difficulties, the Yamaguchi criteria provide the highest sensitivity and accuracy for AOSD diagnosis in current clinical diagnosis. [0003] Adult Still's disease is also characterized by T helper 17 (Th17)-associated cytokines and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL -8 and IL-18; however, the exact pathogenesis remains elusive. Recent reports...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68C12Q1/6883G16H10/40G16H50/30
CPCG01N33/6869C12Q1/6883G16H10/40G16H50/30C12Q2600/178C12Q2600/158G01N2800/102G01N2800/202
Inventor 陈得源杨晶安
Owner 陈得源
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