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Beta-1,3'-galactosyllactose for the treatment of gut barrier function diseases

A technology of intestinal barrier function and intestinal barrier, which is applied in the field of formulas for infants and young children and improving intestinal health, and can solve problems such as incomplete breastfeeding of infants

Pending Publication Date: 2021-12-24
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, breastfeeding a baby is not always possible or desirable

Method used

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  • Beta-1,3'-galactosyllactose for the treatment of gut barrier function diseases
  • Beta-1,3'-galactosyllactose for the treatment of gut barrier function diseases
  • Beta-1,3'-galactosyllactose for the treatment of gut barrier function diseases

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Embodiment Construction

[0011] The present invention relates to the trisaccharide Gal(β1-3)-Gal(β1-4)-Glc, which is used for improving the intestinal barrier function of a subject and / or for preventing and / or treating intestinal barrier damage of a subject.

[0012] The present invention further relates to a nutritional composition for improving the intestinal barrier function of a subject and / or for preventing and / or treating intestinal barrier breakdown in a subject, wherein the nutritional composition comprises trisaccharide as an active ingredient Gal(β1-3)-Gal(β1-4)-Glc(β1,3'-galactosyllactose).

[0013] The present invention further relates to a nutritional composition comprising the trisaccharide Gal(β1-3)-Gal(β1-4)-Glc for use in the treatment, prevention and / or alleviation of a condition associated with toxin exposure in a subject, wherein the toxin Preferably it is a mycotoxin, more preferably it is a trichothecene, and even more preferably the toxin is deoxynivalenol.

[0014] The inventi...

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Abstract

The invention relates to the use of beta1,3'-galactosyllactose for improving the gut barrier function. This can in particular be administered to subjects at risk for increased gut barrier permeability, preferably infants and young children.

Description

technical field [0001] The present invention relates to the field of infant and young child formulas and improving gut health. Background technique [0002] Human milk-fed infants have a lower incidence of infection than formula-fed infants. A number of components in human milk are thought to play a role in protection from pathogen infection, including immunoglobulins (such as sIgA), interleukin (IL)-1, IL-6, IL-8, IL-10, Interferon-γ (IFN-γ), immunocompetent cells, transforming growth factor-β (TGF-β), lactoferrin, nucleotides, and human milk oligosaccharides (HMO). [0003] HMOs are major components in human milk and are non-digestible oligosaccharides (NDOs). Human milk oligosaccharides play a critical role in the postnatal growth and development of the gut and immune system. They promote the growth of good bacteria in the gut. Some HMOs are also known to directly prevent pathogens or toxins from adhering to the intestinal wall. [0004] Human milk is the preferred n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/702A61K9/00A61P1/00A61P3/02A61P43/00A23L33/00
CPCA61K31/702A61P1/00A61P3/02A61P43/00A23L33/40A23L29/30A23L33/125A23L33/12A23L33/17A23L29/04
Inventor S·巴博尔B·鲍特派尔-范特兰德S·P·维尔特塞玛J·加森B·斯塔尔M·曼克
Owner NV NUTRICIA