Application of AD16 in preparation of medicine for relieving chronic inflammatory pain

A technology of chronic inflammation and chronic inflammation, which is applied in the application field of preparing drugs for reducing chronic inflammatory pain, can solve the problems of long treatment course, variable clinical manifestations, and large side effects, and achieve mechanical pain relief, thermal pain relief, The effect of improving the degree of tissue swelling

Active Publication Date: 2021-12-31
GANNAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex pathogenesis of chronic inflammatory pain, variable clinical manifestations, large individual differences, long course of disease and other factors, combined medication is often used in clinical practice with long treatment course and side effects, and the best treatment plan has not yet been found.

Method used

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  • Application of AD16 in preparation of medicine for relieving chronic inflammatory pain
  • Application of AD16 in preparation of medicine for relieving chronic inflammatory pain
  • Application of AD16 in preparation of medicine for relieving chronic inflammatory pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Experimental grouping and processing:

[0026] 31 SD rats (150-170g) were randomly divided into 5 groups, 6-7 rats in each group, respectively control group (Ctrl), model group (CFA group), 0.1mg / kg AD16 treatment group, 0.3mg / kg AD16 treatment group, kg AD16 treatment group, 1mg / kg AD16 treatment group. The model group and the AD16 treatment group were subcutaneously injected with 100 μL of Complete Freund's adjuvant (CFA) once in the left hind foot to prepare animal models of chronic inflammatory pain, and the control group was injected with the same volume of normal saline subcutaneously in the left hind foot. On the second day after modeling, the AD16 treatment group was given AD16 solutions with concentrations of 0.1, 0.3, and 1 mg / mL (DMSO as the solvent), and the volume of administration was 1 mL / kg. The final doses of AD16 were: 0.1, 0.3, and 1 mg / kg, respectively. The control group and the model group were intraperitoneally injected with the same volume of ...

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Abstract

The invention discloses application of AD16 in preparation of a medicine for relieving chronic inflammatory pain. The application of AD16 in the medicine for treating chronic inflammatory pain proves that AD16 can effectively relieve mechanical pain allergy and thermal pain allergy of chronic inflammatory pain and improve the tissue swelling degree of chronic inflammatory pain. AD16 is a medicine which has development potential and is used for treating chronic inflammatory pain.

Description

Technical field: [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of AD16 in the preparation of medicines for alleviating chronic inflammatory pain. Background technique: [0002] Chronic inflammatory pain is one of the diseases that seriously threaten human health. It is common and persists in the course of many diseases, and it still plagues countless patients. Clinically, chronic inflammatory pain is induced by trauma, infection, chemical stimulation or surgical operation. Its main clinical manifestations are redness, swelling, heat, pain and dysfunction. Inflammation is the body's response to injury and infection, involving complex biological regulation of somatosensory, immune, autonomic, and vascular systems. Inflammatory mediators such as prostaglandins, pro-inflammatory cytokines, and chemokines produced during inflammation are directly activated Nociceptors to induce pain. Inflammation-associated changes can le...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61P29/00
CPCA61K31/506A61P29/00
Inventor 胡志苹曹性玲张丽梅黄志华黄诚
Owner GANNAN MEDICAL UNIV
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