Niclosamide injection and preparation and application thereof

A technology of niclosamide and injection, applied in the field of medicine, can solve the problems of bacterial drug resistance, drug resistance and the like, and achieve the effects of improving solubility, expanding use and improving bioavailability

Active Publication Date: 2022-01-11
SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the extensive use of antibiotics has led to serious bacterial resistance, bacterial resistance to traditional antibiotics is one of the most serious problems facing the health of the world today, an effective way to solve this demand is to develop new drugs with Antimicrobial Drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Niclosamide injection and preparation and application thereof
  • Niclosamide injection and preparation and application thereof
  • Niclosamide injection and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] In this example, niclosamide was used as a raw material to develop its injection. Weigh 2g of niclosamide during preparation, add 0.5g-8g of solubilizing agent, add solvent absolute ethanol, propylene glycol, polyethylene glycol or its mixture after mixing, stir to make it dissolve, add buffer after fully dissolving, After mixing, add water to make up to the specified volume. The injection is clear and transparent, with a stable pH, and the minimum inhibitory concentration (MIC) for Staphylococcus aureus-sensitive bacteria and oxygen-resistant Staphylococcus aureus are 0.06 μg / ml and 0.125 μg / ml respectively, establishing Staphylococcus aureus After the mouse skin infection model, after subcutaneous injection of 5mg / kg.bw, 10mg / kg.bw, and 20mg / kg.bw, it was found that the administration group could well prevent and treat the mouse skin infection, and the control group ciprofloxacin group No significant difference. details as follows:

[0031] 1. Experimental material...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a niclosamide injection and preparation and application thereof. The preparation comprises the following steps of: weighing 2g of niclosamide, adding 0.5-8g of a solubilizer, uniformly mixing, adding 50-75ml of a solvent, stirring to dissolve, adding a buffer solution after full dissolution, uniformly mixing, and adding water to a specified volume. The injection is clear and transparent, the pH is stable, the Minimal Inhibitory Concentrations (MIC) of staphylococcus aureus sensitive bacteria and oxygenated-resistant penicillin staphylococcus aureus are respectively 0.06 microgram/ml and 0.125 microgram/ml, and after a staphylococcus aureus mouse skin infection model is established, subcutaneous injection of 5mg/kg. bw, 10mg/kg. bw and 20mg/kg. bw respectively shows that the mouse skin infection can be well prevented and treated by an administration group, and the administration group has no significant difference from a control group ciprofloxacin.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a niclosamide injection and its preparation and application. Background technique [0002] Staphylococcus aureus (S.aureus) widely exists in nature, animals and humans, and can cause serious animal diseases, including abscess, mastitis, arthritis and urinary tract infection. Staphylococcus aureus is a pathogenic bacterium that is often isolated from cow mastitis, and mastitis caused by Staphylococcus aureus is a disease that is difficult to cure. In addition, Staphylococcus aureus can also cause diseases of varying degrees to humans, ranging from small skin infections such as acne, impetigo, cellulitis, carbuncle and other skin syndromes and skin abscesses to life-threatening pneumonia and bacteremia , Endocarditis, sepsis, meningitis, osteomyelitis. Antibacterial drugs are still the most important means of prevention and treatment for the diseases caused by Staphylococcus aureu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/609A61K47/26A61K47/32A61P31/04A61P31/12A61P33/00A61P35/00
CPCA61K31/609A61K9/0019A61K9/08A61K47/26A61K47/32A61P31/04A61P35/00A61P31/12A61P33/00Y02A40/70Y02A50/30
Inventor 刘迎春张微冉金鑫张丽芳谷峰费陈忠王米
Owner SHANGHAI VETERINARY RES INST CHINESE ACAD OF AGRI SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap