Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composite transdermal drug delivery device for multi-channel microneedle electroporation

A drug delivery device and electroporation technology, applied in microneedles, needles, electrotherapy, etc., can solve problems such as limited drug loading, reduced drug treatment effect, and failure to achieve puncture effect

Pending Publication Date: 2022-01-14
BEIHANG UNIV +1
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, with the continuous advancement of 3D printing technology, many tiny and complex microneedles used in medical transdermal drug delivery have been produced, but these microneedles still have shortcomings in drug delivery efficiency and delivery methods. How to solve this problem The first problem is the problem to be solved in the current transdermal administration
Hollow microneedles can significantly increase the amount of drug delivery, and are also helpful for the collection of skin interstitial fluid. However, the hollow microneedles currently appearing only open holes in the middle of the microneedles, which limits the drug delivery to the epidermis of the skin. A certain cross-section of the drug, thereby reducing the therapeutic effect of the drug
[0005] Due to the current preparation of polymer microneedles, different types of microneedles are prepared, and the drug delivery effects achieved are very different. Often, the forming effect of the microneedles is guaranteed, but the drug loading is limited, or the drug loading is improved. The proportion of the drug in the microneedle body, but the ideal puncture effect cannot be achieved. This is the reason why domestic polymer microneedles have not achieved both high efficiency and high precision.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composite transdermal drug delivery device for multi-channel microneedle electroporation
  • Composite transdermal drug delivery device for multi-channel microneedle electroporation
  • Composite transdermal drug delivery device for multi-channel microneedle electroporation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The multi-channel microneedle electroporation composite transdermal drug delivery device designed by the present invention is an array formed by straight microchannels and evenly arranged microneedles; the transdermal drug delivery device includes microneedle parts and The electroporation part; the microneedle part is a multi-channel conical microneedle array, the height of the microneedle body is 500 μm, and the maximum diameter of the bottom is 350 μm.

[0026] The material of the microneedle body is a photosensitive hard resin; the microneedle drug storage tank can carry medicines such as analgesics, anesthesia, and vaccines; Tank part.

[0027] The microneedle array is every 0.25cm 2 36 multi-flow channel microneedles are evenly arranged, and the vertical and horizontal microneedles are equally spaced apart, and 2 hollow microneedles are arranged every 1 mm in the row; the microneedle body is 8-hole type, and the pore diameter is 30 μm; The wall thickness of the l...

Embodiment 2

[0030] The multi-channel microneedle electroporation composite transdermal drug delivery device designed by the present invention is an array formed by straight microchannels and evenly arranged microneedles; the transdermal drug delivery device includes microneedle parts and The electroporation part; the microneedle part is a multi-channel conical microneedle array, the height of the microneedle body is 700 μm, and the maximum diameter of the bottom is 500 μm.

[0031] The material of the microneedle needle body is a photosensitive hard resin; the part of the microneedle drug storage tank can carry pain relievers (morphine, heroin, codeine, nalamorphine, alfarodine, meperidine, fentanyl, etc.) , methadone, pentazocine, dihydroetorphine, tramadol, butcinazine, tetrahydropalmatine, rotundine, phenothiazine), anesthetics (procaine, tetracaine, lidocaine bupivacaine), vaccines (influenza vaccine, hepatitis vaccine, sterile rabies vaccine, Japanese encephalitis vaccine, chickenpox...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Heightaaaaaaaaaa
Diameteraaaaaaaaaa
Apertureaaaaaaaaaa
Login to View More

Abstract

The invention discloses a composite transdermal drug delivery device for multi-channel microneedle electroporation which comprises a multi-channel microneedle, an electroporation device and a drug storage chamber. According to the device, the drug delivery process and the electroporation process are carried out at the same time, the multi-channel microneedle pierces the cuticle to reach the epidermal layer, a barrier for the drug to enter subcutaneous tissue is broken through, the electroporation device provides current, and under the guiding effect of the electron flow direction, the drug is delivered to the epidermal layer from the drug storage chamber in a targeted mode in an accelerated mode. And under the action of an electric field, the medicine breaks through cell membranes and quickly enters cells. According to the multi-channel microneedle, the straight holes are uniformly distributed in the microneedle body, the straight holes are communicated with the drug storage chamber, the multi-channel microneedle and the drug storage chamber are connected into an integrated system through the electroporation device, and the whole system rapidly delivers drugs into cells in a targeted mode to play a role.

Description

technical field [0001] The invention belongs to the field of medical micro-nano equipment, and relates to a preparation method of a multi-channel polymer microneedle, and relates to electroporation microneedle composite transdermal drug delivery, which improves the efficiency of drug delivery. Background technique [0002] In recent years, with the continuous advancement of 3D printing technology, many tiny and complex microneedles used in medical transdermal drug delivery have been produced, but these microneedles still have shortcomings in drug delivery efficiency and delivery methods. How to solve this problem The first problem is the unresolved problem of percutaneous drug delivery. [0003] Microneedles are arrays of submillimeter-sized needles (50-1000 μm), minimally invasive means bypassing the stratum corneum (SC), forming micron-scale transient drug delivery paths, and enabling therapeutic agents to enter the epidermis while enhancing penetration. skin permeability...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61M37/00A61N1/40
CPCA61M37/0015A61N1/40A61M2037/0023A61M2037/0007A61M2037/0053A61M2037/003
Inventor 庄俭林龙王玉琼常凌乾孙靖尧吴大鸣康婷婷赵泽伟朱龙
Owner BEIHANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com