Reagents and methods for cancer detection, prognosis, and therapeutic monitoring

A technology for cancer treatment and cancer, which is applied in the field of diagnosing cancer, predicting cancer occurrence or recurrence and/or monitoring cancer treatment, and can solve problems such as metastatic disease that cannot be cured

Pending Publication Date: 2022-02-18
SANFORD HEALTH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Only 5% of U.S. women develop metastatic basal cell carcinoma at first diagnosis; however, most BCa-related deaths are due to incurable metastatic disease rather than initial diagnosis

Method used

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  • Reagents and methods for cancer detection, prognosis, and therapeutic monitoring
  • Reagents and methods for cancer detection, prognosis, and therapeutic monitoring
  • Reagents and methods for cancer detection, prognosis, and therapeutic monitoring

Examples

Experimental program
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Embodiment

[1042] Example / Case Study 1

[1043] Serum samples from 200 newly diagnosed breast cancer patients were stained for ANA before starting any treatment. This patient population represented heterogeneity of disease, including 74% invasive, 26% in situ, 87% ductal, 11% lobular, 24% nodal involvement, 86% ER positive, 17% of HER-2-positive and 12% of triple-negative breast cancers. HEp-2 cells were seeded in 96-well tissue culture plates. Cells were fixed, permeabilized, and incubated with serum samples at an initial dilution of 1:40. Secondary antibody AlexaTM 488 goat anti-human IgG was added for pattern detection. Cells were imaged using a CellInsight CX7TM instrument. Positive samples diluted at 1:40 were further screened with 1:2 serial dilutions of 1:40, 1:80, 1:160, and 1:320. Staining patterns were scored independently by two scientists to ensure accuracy and reproducibility of pattern determination. Reference sera for each staining pattern were obtained from SLR Rese...

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Abstract

Methods and related reagents are disclosed for diagnosing cancer, prognosing cancer occurrence or recurrence, and / or monitoring cancer therapy, involving contacting a bodily fluid sample from a subject at risk of having cancer or cancer recurrence, or from a subject that has been treated for cancer wl fit (a)one or more first antibody detection marker molecules that hind to human autoantibodies against at least one tumor associated antigen (TAA); and (fa) one or more second antibody detection marker molecules that bind to human autoantibodies against at least one extractable nuclear antigen (ENA).

Description

[0001] cross reference [0002] This application claims priority to U.S. Provisional Patent Application No. 62 / 859,264, filed June 10, 2019, which is hereby incorporated by reference in its entirety. [0003] Federal Funding Statement: [0004] This invention was made with Government Support No. P20GM103548 awarded by the National Institutes of Health and #1R44CA217447-01 awarded by the National Cancer Institute. The government has certain rights in this invention. [0005] Statement Regarding Sequence Listing [0006] This application contains a Sequence Listing submitted as an electronic text file "17-689-PCT_Sequence-Listing_ST25.txt" created on June 4, 2020, with a size (bytes) of 152kb. Pursuant to 37 CFR §1.52(e)(5), all information contained in this electronic document is incorporated by reference. Background technique [0007] The 5-year survival rate for women diagnosed with localized breast cancer (BCa) is 98.6%. Local stage survival dropped to 83.8% and long te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/574G01N33/57415G01N2333/8125
Inventor 克里斯提·艾格兰德瑞克·伊万斯伊加帕纳特·蒂鲁帕蒂大卫·优尔马特·考斯图拉艾蒂安·格尼皮巴
Owner SANFORD HEALTH
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