Novel pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders
A technology for mental disorders and cognitive disorders, applied in the field of practical medicine, to solve problems such as no cure, cure AD or prevent loss
Pending Publication Date: 2022-02-18
LA PHARMA TECH INC
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0005] However, acetylcholinesterase inhibitors such as donepezil, rivastigmine and galantamine will not cure AD or prevent the loss of these abilities at some point in the future
Therefore, there is currently no cure for AD and the inventors' efforts are to find better ways to reverse the disease, delay and prevent its progression
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment 1
[0045] Diagnosed with advanced Alzheimer's disease, MMSE score 10-1 and NPI-Q severity with a once-daily tablet form of a pharmaceutical composition comprising 12 mg azelastine HCl and 3 mg donepezil HCl Ten patients with a score of 3 and a pain score of 4 or 5. After 12 weeks, these 10 patients would have increased their MMSE scores by at least 9 points into the 20-10 point range, a 1- to 9-fold improvement in MMSE scores, and their NPI-Q would have had a severity score of 1 and a severity score of 1. Or a pain score of 2 points, an improvement of 2.5x to 4x.
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A pharmaceutical composition containing the therapeutically active ingredients of azelastine or a pharmaceutically acceptable salt of azelastine and donepezil or rivastigmine or galantamine or a pharmaceutically acceptable salt of thereof is disclosed. A method of using the pharmaceutical composition for treating patients suffering from mental, behavioral, cognitive disorders is also disclosed.
Description
technical field [0001] The present invention relates to the field of applied medicine, i.e. to displaying neurotropic action, alleviating clinical manifestations of mental disorders, behavioral disorders, cognitive disorders in the case of organic damage of various origins to the central nervous system combination of pharmaceutical compositions. Background technique [0002] Alzheimer's disease (AD) is a progressive, chronic neurodegenerative disease that usually begins slowly and progressively worsens over time. Among older adults, Alzheimer's disease is the most common cause of dementia. Dementia is the loss of cognitive function (thinking, memory, and reasoning) and behavioral abilities to the extent that it interferes with a person's daily life and activities. In its early stages, memory loss is mild, but in advanced AD, individuals lose the ability to carry on conversations and respond to their environment. If left untreated, AD eventually leads to death. Typical li...
Claims
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IPC IPC(8): H01M10/04H01M10/26H01M4/00
CPCA61K31/55A61K31/445A61K31/27A61P25/28Y02P70/50A61K2300/00
Inventor 王建民崔歌平
Owner LA PHARMA TECH INC
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